Research shows that imbalance of intestinal flora can promote the attack of colorectal cancer

Recently, published in the journal PNAs, a study from the Department of Microbiology of Coll è Ge University in France shows that imbalance of intestinal flora can promote the onset of colorectal cancer The researchers found that transplanting fecal flora from colon cancer patients to mice can cause pathological changes and epigenetic changes in the development of cancer In this study, 136 mice were transplanted with fresh feces from nine patients with sporadic colorectal cancer or nine patients without colon disease The colon of mice was examined 7 and 14 weeks after transplantation The number and deterioration of abnormal crypt foci (or ACF, a precancerous lesion type), microbial characteristics and DNA damage of colon were studied They also measured food intake, body weight and blood parameters The association between fecal malnutrition (imbalance of bacterial composition in the gut) and genetic and epigenetic DNA markers in animal tissues has been confirmed by statistical tests In mice that received fresh feces from patients with sporadic colorectal cancer, abnormal crypt foci (ACF) were found, which are considered to be one of the precancerous lesions However, there was no significant genetic change in colon tissue We hope to develop a simple and reusable blood test for early diagnosis of colorectal cancer in asymptomatic patients This study shows that the microflora of patients with sporadic colorectal cancer can induce precancerous colonic lesions in animals by highly methylation of a few genes Therefore, CMI and / or methylated bacteria can be used as diagnostic markers for this type of cancer Of course, these preliminary findings need to be evaluated and confirmed in clinical trials (http://