Researchers develop more effective anti-cancer drugs from natural products

Ipomoeassin F is a member of the resin glycoside family, a common secondary metabolite characteristic of bovine flowersIpomoeassin F can significantly inhibit the growth of a variety of tumor cell lines, which is comparable to many clinical anticancer drugs, but so far researchers have not been able to understand its biological and pharmacological mechanismspicture source: Zhijian Hu, ph.d.ein jacS' Department of Chemistry and Biochemistry, tested the cytotoxicity of nearly 60 contemporaries with similar structures to study the structural characteristics of Ipomoeassin FHu then discovered that Sec61 alpha was a key protein for the binding of biotin and Sec61 alpha using similars containing biotinFluorescent imaging confirms this findingThe researchers found that fluorescent signals are confined to the inner mesh, a cytoplasmic membrane of eukaryotic cells settled by Sec61 alphaHu further verifies that Sec61 alpha is the primary molecular target with immunoprinting (commonly used to detect and analyze proteins)study, published in Journal of The American Chemical Society, provides a new molecular tool to learn more about The Se61 alpha properties and new targets for potential therapeutic drug discoveryReferences: Guanghui Zong et alIpomoeasin F Binds Sec61 alpha to Inhibit Protein Translocation, Journal of the American Chemical Society (2019)DOI: 10.1021/jac.8b13506