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The Golden Gate Bridge has extremely beautiful scenery and amazing height, and it definitely deserves its title as one of the modern wonders of the world
Our brains have similar channels connecting neurons, albeit on a small scale
In an article recently published in the journal Science Advances, Max Planck's Taniguchi laboratory in Florida shed light on a new mechanism of inhibitory synapse specificity in the cerebral cortex
"Our laboratory specializes in the formation of cortical interneurons and inhibitory circuits," said Dr.
MPFI scientists began their research, using single-cell RNA sequencing to genetically screen specific subtypes of INs genes
The first author of the paper, Dr.
CAMs are composed of a group of different structural proteins
After determining that IgSF11 is a homologous CAM, the MPFI team looked for the expression of IgSF11 in neurons in the upper half of the 2/3 layer of the cortex innervated by ChCs, and believed that the homologous CAM interaction needs to be expressed on both sides
Next, the Taniguchi lab evaluated the functional role of IgSF11 in ChC synapse formation by removing IgSF11 from the brain and examining its changes
The cooperation with MPFI's Electron Microscopy Center and Kwon Laboratory has further studied the functional consequences of KO IgSF11
"One of the challenges with using chandelier cells is that it is difficult to genetically manipulate them using traditional methods," explains Dr.
The MPFI team used their AAV virus strategy to investigate whether the expression of IgSF11 in neurons in different cortical layers (except the 2/3 layer) can artificially induce the formation of synapses with ChCs
Taniguchi pointed out: "IgSF11 is the first cell adhesion molecule identified as directly mediating the formation of cortical neuronal subtypes and neuronal layer-specific synapses
Original Search: IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype
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About Max Planck Florida Institute of Neuroscience
The Max Planck Florida Neuroscience Institute (MPFI) is a non-profit research organization that is part of the world-renowned Max Planck Society