echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Researchers find drug-resistant environmental mold capable of infecting humans

    Researchers find drug-resistant environmental mold capable of infecting humans

    • Last Update: 2022-05-14
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    The researchers found six patients infected with a drug-resistant fungus called Aspergillus fumigatus, which can be traced to spores in the environment


    Aspergillus fumigatus is an environmental mold that causes fungal lung disease


    This resistance has evolved because of the widespread use of azole fungicides in agriculture, the scientists said


    The researchers called for increased monitoring of A.


    Senior author Professor Matthew Fisher, from Imperial's School of Public Health, said: "Understanding environmental hotspots and the genetic basis of the evolution of resistance in fungi requires urgent attention, as resistance is compromising our ability to prevent and treat the disease


    He added: "The prevalence of drug-resistant aspergillosis has risen from negligible levels before 1999 to now account for 3-40% of cases across Europe


    For the study, researchers isolated 218 A.


    The researchers extracted DNA from mold samples and sequenced them to determine whether there was a crossover of drug-resistant spores found in the environment and in some patients


    They found six strains of A.


    Lead author Dr Johanna Rhodes, from the Royal Medical Research Council Centre for Global Disease Analysis at the School of Public Health, said: "An increasing number of cases of aspergillosis are becoming resistant to first-line azoles


    Of the 218 samples, nearly half (106 samples) developed resistance to at least one azole drug in first-line clinical use


    In 218 samples, the researchers identified 50 new genes associated with drug resistance


    By looking at the genes of the A.


    The findings suggest that the full extent of azole resistance in Aspergillus fumigatus remains to be understood, the scientists said


    Dr Rhodes said: "Our findings highlight new ways in which drug-resistant infections can spread to humans and demonstrate the need for a better understanding of where and how A.


    The research was funded by the Natural Environment Research Council, the Wellcome Foundation, and the Gilead Sciences and Medical Research Council


    Journal Reference :

    1. Rhodes, J.
      , Abdolrasouli, A.
      , Dunne, K.
      et al.
      Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment .
      Nat Microbiol , 2022 DOI: 10.
      1038/s41564-022-01091-2  2022 ).


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.