Researchers have developed a self-organized embryonic body platform that can replace some animal experiments

Researchers at the University of Bonn have developed a method to generate embryonic-like cell complexes from stem cells in mice

People do not fully understand how mice, dogs, or humans develop from fertilized egg cells

This process must be coordinated to the smallest details

Modified cell lines can self-organize

Current research allows for new insights into these precise coordination processes

However, they obviously play a decisive role in embryonic development: if ES cells are stimulated to divide, they just become a group of undifferentiated cells

When the researchers combined these two modified cell lines with the original embryonic stem cells, they observed something amazing: the mouse cells differentiated in a finely balanced way, eventually producing an embryo-like compound Body-an embryoid body

Embryo-like bodies can replace animal experiments

It has been possible to make such embryoid bodies before

Currently, Professor Scholler is planning to create this embryo-like body from monkey embryonic stem cells in a very similar way

Nature Communications

DOI

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