Researchers have developed shape-memory multichannel nerve repair catheters.

Recently, Zhao Xiaoli, a researcher at the Center for Human Tissue and Organ Degeneration of the Institute of Advanced Technology of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, worked with Fan Xuanyi, professor of orthopaedics at the Sixth People's Hospital affiliated with Shanghai Jiaoda University, to develop a rapid self-forming multi-channel neural catheter based on the shape memory nanofiber membrane to promote the extension of nerve synapses and the repair of peripheral nerve long-term defects.
research was published on ACS Nano under the title Bioinspired Multichannel Nerve Guidance Conduit Foundation on Shape Memory Nanofibers for Potential Application in Permed Nerve Repair.
Jing of Shenzhen Advanced Hospital and Xiong Hao of the Sixth People's Hospital affiliated with Shanghai Xuanda University are co-authors of the paper, and Shenzhen Advanced Hospital is the first communication unit of the thesis.
long-term nerve defects lead to impaired target organ function and a higher rate of disability.
multi-channel neural catheters with bionic natural nerve beams can prevent axon dispersion and reduce nerve misalmishing, which is conducive to the recovery of nerve function.
research team introduced the shape memory polymer of temperature response into the construction of nerve catheters, prepared double-layer nanofiber membranes by electrostational spinning technology, realized hypothermia deformation response by using the shape memory characteristics of the material itself, and quickly constructed multi-channel neural catheters;
the construction method of the neural catheter realizes the uniform load and high density growth of the shervan cells in the catheter, and the inner wall structure of the orientation catheter promotes the extension of the nerve synapse.
in the mouse squirrel nerve defect model, the multi-channel catheter was constructed to promote defective nerve regeneration and functional recovery.
this study provides new strategies and methods for the construction and preparation of neural catheters and new treatment options for the repair of long-term nerve defects around clinical practice.
(Bioon.com)