Researchers identify key regulator of urine concentration in kidney

The proper function of the kidneys is essential for centralizing urine, regulating blood pressure, and tightly controlling electrolyte levels in the blood

A team of MGH researchers has now investigated which factors control the formation and function of specific parts called distal nephrons

The distal nephron is particularly important for the kidneys to concentrate urine, regulate blood pressure, and control blood calcium and magnesium levels

Alexander G.

Previously, in research published in Developmental Cell in 2020, Marneros showed that AP-2β is required for the formation of the part of the distal nephron targeted by thiazide diuretics: the distal convoluted tubule

These findings suggest that AP-2α and AP-2β are important regulators of different segments of the distal nephron

He added: "A detailed understanding of the mechanisms that not only lead to the formation of distal nephron fragments, but also maintain the normal function of these fragments in adults, will be critical for future new approaches to the treatment of various kidney diseases