Researchers reveal SARS-CoV-2 evolutionary network 'primitive type' is common in US and Australia

In fact, the origin of SARS-CoV-2 has been controversial since its inceptionA new study published in PNAS recently sheds light on the origin and path of the virus and suggests that more virus genome types are emerging in the United States and Australia that are close to the original coronavirusresearchers from the University of Cambridge and Germany in the United Kingdom used gene networking technology to reconstruct the early "evolutionary pathway" of SARS-CoV-2 in humans, and found that the virus in this process mainly exists in the a, B, C three types of mutations, of which Class A and the coronavirus extracted from bats and pangolins are most similarhttps://doi.org/10.1073/pnas.2004999117February 3rd, a study published in Nature by Professor Shi Zhengli of the Wuhan Institute of Viruses of the Chinese Academy of Sciences found that the genome of SARS-CoV-2 is 96% similar to that of bat coronavirusesBased on this, the study set the bat coronavirus as its originresearchers mapped the virus evolutionary network using early 160 viral genomic data from the Global Influenza Sequence Database (GISAID) and identified three core variants of SARS-COV-2:-A: closest to bat coronavirus;-B type: type A derived from synonymous mutation C28144T;-C-type: derived from the Non-Identical G244specifically, in the data set, Type A is the "root of the outbreak", which, although wuhan exists, is not the main local virus type, with nearly half of those infected in the United States and AustraliaType B is more common in Wuhan and throughout East Asia, where only 19 genomes originate outside East Asia and have evolved mutations, possibly because of resistance to this type of virus outside East AsiaType C is mainly a European virus type found in early patients in France, Italy, Sweden and the United Kingdom, and although no C variant was found in the Chinese mainland sample, it was found in samples from Singapore, Hong Kong and South Koreaa systematic evolutionary network of 160 SARS-CoV-2 genomesusing the SARS-CoV-2 gene evolutionary network, the researchers also reconstructed the path of infection in some countriesFor example, the virus first entered Italy not only because of the first documented infection son-in-law in Germany on January 27th, but also because of the "Singapore group infection" incidentit is understood that since the study because of this, researchers have expanded their analysis to 1,001 viral genomes Although not peer-reviewed, Michael Forster, the study's lead author, said the latest research suggests that the first infection and spread of COVID-19 occurred between mid-September and early December So far, the cumulative number of confirmed cases worldwide has exceeded 2 million, and the cumulative number of deaths has reached nearly 120,000, and the epidemic continues to spread References: s1 s coVID-19: Genetic network analysis provides 'snapshot' of the pandemic origins 2 s Phylogenenetwork analysis of SARS-CoV-2 Genomes .
3 S Nature apologizes to China for the third day in a row! Original title: PNAS: Cambridge scholar reveals SARS-CoV-2 evolutionary network, "original type" is mostcommonin US and Australia