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    Home > Biochemistry News > Biotechnology News > Researchers use the power of nature to improve anti-cancer antibody therapy

    Researchers use the power of nature to improve anti-cancer antibody therapy

    • Last Update: 2021-09-10
    • Source: Internet
    • Author: User
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    Researchers from the University of Southampton and UCB Biopharmaceuticals have discovered a way to use the complement cascade part of the human immune system to enhance the natural ability of therapeutic antibodies to attack blood cancer cells.


    The new technology published in "Communication Biology" takes advantage of the natural properties of immunoglobulin M (IgM), which has a natural high level of complement activation, and builds this property into immunoglobulin G (IgG) ) Among antibodies, this is the preferred choice for the treatment of human diseases


    This new method uses innovative but simple protein engineering, combined with an improved IgM'tailpiece', and has been proven effective in several different antibodies


    This research was a joint doctoral student project funded by the UKRI government and UCB, and was completed by a collaboration between blood cancer experts from the University of Southampton and antibody engineering experts from the biopharmaceutical company UCB


    UCB researchers, Dr.


    DOI

    10.


    On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

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