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Researchers from the University of Southampton and UCB Biopharmaceuticals have discovered a way to use the complement cascade part of the human immune system to enhance the natural ability of therapeutic antibodies to attack blood cancer cells.
The new technology published in "Communication Biology" takes advantage of the natural properties of immunoglobulin M (IgM), which has a natural high level of complement activation, and builds this property into immunoglobulin G (IgG) ) Among antibodies, this is the preferred choice for the treatment of human diseases
This new method uses innovative but simple protein engineering, combined with an improved IgM'tailpiece', and has been proven effective in several different antibodies
This research was a joint doctoral student project funded by the UKRI government and UCB, and was completed by a collaboration between blood cancer experts from the University of Southampton and antibody engineering experts from the biopharmaceutical company UCB
UCB researchers, Dr.
DOI
10.