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    Home > Active Ingredient News > Infection > 【Research】Professor Chen Peng's team from Jilin University revealed the association between non-alcoholic fatty liver disease and severe novel coronavirus pneumonia

    【Research】Professor Chen Peng's team from Jilin University revealed the association between non-alcoholic fatty liver disease and severe novel coronavirus pneumonia

    • Last Update: 2022-06-14
    • Source: Internet
    • Author: User
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    Introduction: With the development of society and economy, the improvement of people's living standards and the change of life>
    .

    Indeed, non-alcoholic fatty liver disease (NAFLD) has now become the most common chronic liver disease in the world.
    According to research statistics, 25 out of every 100 people suffer from NAFLD[1]
    .

    Today, when the new coronavirus pneumonia (new crown) is raging around the world, it is generally believed that the underlying disease is the main driving factor for the development of the new crown into severe disease
    .

    Severe cases here refer to hospitalization, use of ventilators and even death, which are the main reasons why China adopts "dynamic clearing" anti-epidemic measures
    .

    Currently, known risk factors for severe COVID-19 include obesity, diabetes, and chronic kidney disease
    .

    However, whether NAFLD increases the risk of severe COVID-19 remains inconclusive (Fig.
    1)
    .

    Figure 1.
    What is the relationship between NAFLD and severe new crowns Increased risk of severe COVID-19 through obesity, a complication of NAFLD
    .

    The research results have been published in the international authoritative journal "Clinical gastroenterology and hepatology" (Fig.
    2) [2]
    .

    Figure 2.
    Corresponding author Professor Chen Peng of the research article on the association between NAFLD and severe COVID-19 said that obesity and type 2 diabetes in endocrine and metabolic diseases have been shown to increase the risk of severe COVID-19, but NAFLD is a common endocrine metabolic disease Sexually transmitted diseases, its link to severe COVID-19 remains ambiguous
    .

    This project uses observational studies and Mendelian randomization studies to corroborate each other and further disentangle the relationship between the two
    .

    Professor Chen Peng's team found that among 8,267 European patients with new coronavirus infection, after removing the effects of age, gender, BMI, liver cirrhosis, type 2 diabetes, cardiovascular disease and blood pressure, there was no significant correlation between NAFLD and severe new crown virus ( Fig.
    3)
    .

    That is: NAFLD itself does not increase the risk of severe COVID-19
    .

    Figure.
    3 Correlation between NAFLD and severe COVID-19 If the results of the above observational studies are susceptible to confounding factors, the team’s further causal inference analysis also confirmed that NAFLD is not a risk factor for severe COVID-19 (Figure.
    4)
    .

    In addition, the results of the study also showed that among NAFLD comorbidities, only obesity-related traits (such as BMI, hip circumference, waist circumference) increased the risk of severe new coronary disease
    .

    Figure 4.
    The causal relationship between NAFLD and severe COVID-19 As shown in Figure 5, although NAFLD itself does not increase the risk of severe COVID-19, if it is accompanied by obesity, the risk of severe COVID-19 will still increase
    .

    Figure 5.
    There is no significant association between NAFLD and severe COVID-19.
    The results of this study suggest that weight control may help prevent the occurrence of severe COVID-19
    .

    During quarantine or lockdown, weight control is even more important, which can help reduce the severity of severe COVID-19
    .

    Finally, Professor Chen Peng said: This study is mainly based on a small sample of European population, and the results of the study still need to be verified by a larger sample cohort
    .

    In addition, whether the conclusions of this study are applicable to other races also needs to be further explored
    .

    Reference: [1] YOUNOSSI ZM, KOENIG AB, ABDELATIF D, et al.
    Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes [J].
    Hepatology (Baltimore, Md), 2016, 64(1): 73-84.
    [2] LI J, TIAN A, ZHU H, et al.
    Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19 [J].
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022, Note: This article is intended to introduce medical research progress and cannot be used as a reference for treatment plans
    .

    For health guidance, please go to a regular hospital for treatment
    .

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