Respiratory Res: Hyalurallic acid helps treat chronic lung disease

February 2, 2021 /--- Researchers at the National Institutes of Health and its collaborators have found that inhaling debris-free hyalurinoic acid improves lung function in patients with chronic obstructive pulmonary disease (COPD).
hyaluracin is a sugar secreted by biological tissue that can be used as a stent for cells or as a skin moisturizer and nasal spray in cosmetics to moisturize the lungs and respiratory tract.
hyalurinoic acid is used as a treatment, reducing the amount of time COPD patients in intensive care need breathing support, reducing the number of days they spend in hospital, and saving financial costs by reducing hospital stays.
study, published online in The Journal of Research, is a good example of how the effects of environmental pollution on the lungs lead to viable treatments.
years ago, Dr. Stavros Garantziotis, medical director of clinical research at the National Institutes of Health (NIH) and co-senior author, said exposure to pollution causes hyalurinoic acid in the lungs to break down into smaller fragments.
these fragments stimulate lung tissue and activate the immune system, leading to airway contraction and inflammation.
, fragment-free hyalurinoic acid overcomes smaller hyaluric acid fragments, thereby reducing inflammation.
(Photo: www.pixabay.com) Garantziotis provides an analogy of how inflammation occurs.
, he says, hyalurino acid surrounds cells like mortar around bricks.
into the mold can cause the mortar to break up and break it into small pieces.
smaller blocks stimulate the body and activate the immune system, leading to inflammation," said Garantziotis, a government ad-year-old.
reintroduced full-length hyalurinoic acid, like fresh mortar, which means it is less irritating and reduces inflammation.
since hyaluric acid was approved for respiratory moisturizing in Italy, Garantziotis has worked with colleagues in Rome to see if inhaling full-size hyalurinoic acid can improve lung function in patients with severe COPD.
he explained that patients are using respirators similar to those used in continuous respiratory positive pressure ventilators (CPAP) to treat the acute exacerbation of COPD.
the device provides breathing support by blowing air through the mask into the airways.
, M.D., of the Campus Biomedical University and the Rome Teaching Hospital, said: "Inhaled hyalurino acid stimulates patients with worsening COPD because it is safe and easy to manage.
addition, it only works in the branch and therefore does not interfere with any systemic drugs.
" Garantziotis also wanted to know what caused the narrowing of the respiratory tract in the lungs of COPD patients.
he speculated it might be sticky mucus.
worked with scientists at the University of Alabama at Birmingham (UAB) to develop respiratory cells in emphysema patients and to study how mucus move in cells.
found that mucus was more likely to flow out after taking hyalurinoic acid.
Steven Rowe, director of the UAB Gregory Fleming James Cystic Fibrosis Research Center, said that if severe COPD patients take hyaluracin, the treatment will improve mucus transport and help them recover.
(Bioon.com) Source: Study show hyaluronan is effective in treating chronic disease Original source: Flavia Galdi et al, Inhaled high molecular weight hyaluronan ameliorates resailly failure acute in COPD agency: a pilot study, Carey Research (2021). DOI: 10.1186/s12931-020-01610-x