Retrospective study: The neurological diseases caused by varicella-zoster virus after vaccination with COVID-19 are no different from those without vaccination

In the ongoing global COVID-19 vaccination plan, the description of every possible adverse reaction or event related to the vaccine is mandatory
.

Although more and more cases of skin varicella-zoster virus (VZV) reactivation after COVID-19 vaccination are reported in the literature and databases, there is still a lack of descriptions of VZV-induced neurological diseases (VZV-ND)

COVID-19 diagnosis

During January-April 2019, January-April 2020, and January-April 2021, we respectively identified 6, 7 and 9 patients diagnosed with VZV-ND who were admitted to our department
.

During January-April 2021, 3 cases were vaccinated against COVID-19 before clinical onset, while 6 subjects were not vaccinated

We identified 3 patients with VZV-ND who were vaccinated against COVID-19 and 19 cases without VZV-ND as controls

All fully exploratory comparisons show that the vaccinated and unvaccinated patients are in demographics (age, gender, time from onset to LP), CSF parameters (white blood cell count, protein, lactate, CSF/serum albumin ratio, There was no statistically significant difference in VZV-AI increase, OCB positive, VZV-DNA-PCR positive/cutoff) and outcome
.

All fully exploratory comparisons show that the vaccinated and unvaccinated patients are in demographics (age, gender, time from onset to LP), CSF parameters (white blood cell count, protein, lactate, CSF/serum albumin ratio, There was no statistically significant difference in VZV-AI increase, OCB positive, VZV-DNA-PCR positive/cutoff) and outcome
.

For MRI and EEG data, it is impossible to make comparisons due to the small sample size
.

Table 2 : Demographic, clinical characteristics and diagnostic survey results of VZV-ND vaccination cases

Table 2 inoculation VZV-ND cases demographic, clinical features and diagnostic findings inoculation VZV-ND cases demographic, clinical features and diagnostic findings

Table 3 : Cerebrospinal fluid examination results of VZV-ND cases

Table 3 : Cerebrospinal fluid examination results of VZV-ND cases Table 3 : Cerebrospinal fluid examination results of VZV-ND cases

In summary, in the case-control analysis, there was no difference between the two groups in terms of clinical features, diagnostic research results, and outcomes
.

Our data and accompanying observations indicate that VZV reactivation may be a rare event triggered by COVID-19 vaccination.

In summary, in the case-control analysis, there was no difference between the two groups in terms of clinical features, diagnostic research results, and outcomes

Original link: https://pubmed.

Varicella zoster virus-induced neurological disease after COVID-19 vaccination: a retrospective monocentric study in this message