"Return" young is expected! Diluted plasma reverses aging and restores tissue life, new study finds

Guide: Replacing half of the plasma of elderly mice with a mixture of saline and albumin can reverse signs of aging and breathe life into the tissueaging is an irresistible natural law, with the age of the biological function will gradually declineHowever, since ancient times, human beings have the dream of eternal life, eager to return to old children, eternal youthThat's why humans have been looking for ways to overcome aginga recent study published in Aging has helped the "tug- of human aging" and showed that aging is reversible, not statica team at the University of California, Berkeley, found in mouse experiments that replacing half of the plasma of older mice with a mixture of salt water and albumin could reverse signs of aging and breathe life into tissueIn fact, as early as 2005, researchers found that when young mice shared blood and organs with older mice, the tissues of older mice were rejuvenated and signs of aging were reversedThe results led researchers to further explore whether young blood was the source of spring in miceHowever, a 2016 study published in Nature Communications noted that the regeneration does not appear to be due to young blood, which also showsigns of aging when young mice are injected into older bloodThe researchers hypothesized that, as they age, the build-up of certain proteins may be the primary inhibitor of tissue maintenance and repair, while diluting these proteins through blood exchange can restore the original mechanism"Aging may be caused by a brief and reversible decline in regeneration," said Irina Conboy, a professor of bioengineering at the University of California, Berkeley,the report's lead authorEven if someone is older, they can generally return to the younger level by replacing broken cells and tissues with healthy cells and tissues, and this ability is regulated by specific chemicals that change with age, which can be counterproductiveTo test this hypothesis, the researchers came up with the idea of a "neutral" blood exchange (NBE), in which the blood is diluted by replacing a portion of plasma with salt water and a protein called albuminThe results showed that physiological saline containing 5% albumin significantly improved the health of older mice, enhanced muscle repair, reduced liver fat and fibrosis, and increased the recovery of hippocampus nerves in older mice, making it no significant difference from the young micethe recovery of muscle regeneration in older mice
the researchers performed proteomic analyses on mouse plasma to understand changes in proteins in the blood after replacement, and similar lying with human plasma that had undergone therapeutic plasma replacement (TPE) They found that the plasma replacement process, like a molecular reset button, reduced the concentration of a variety of pro-inflammatory proteins that increased with age, while causing more beneficial proteins to bounce back in large quantities comparison of NBE / TPE proteomics
Dr Dobri Kiprov, medical director of the Apheresis Care Group and one of the report's authors, said: "I hope our findings open the door to further research on the use of plasma exchange - not only for aging, but also for immunomodulation." currently, the team is conducting clinical trials to better understand how therapeutic blood exchange is best used to regulate human aging and treat age-related diseases, including muscular dystrophy, neurodegenerative diseases, type 2 diabetes, and immunomodulation disorders References: .S a single heterochronic blood exchange skicks rapid arion multiple sby old blood