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| Reveal the key molecular mechanism of human telomere DNA synthesis |
Recently, the team of Li Guohui, a researcher at the Dalian Institute of Chemical Physics , Chinese Academy of Sciences, and the team of Lei Ming and Wu Jian, professors at the School of Medicine of Shanghai Jiaotong University, have made new progress in revealing the key molecular mechanisms of human telomere DNA synthesis
.
Related results were published in "Cell Research"
Chinese Academy of Sciences
Telomeres are DNA-protein complexes located at the ends of eukaryotic chromosomes, which are used to protect the integrity of chromosomes during cell division
.
Telomere DNA will gradually shorten with each cell division.
In the process of cell division, telomerase will also be activated at the same time to synthesize telomere DNA to compensate for the loss of telomeres in this process
.
Human telomerase is a multi-subunit ribonucleoprotein complex with reverse transcriptase activity.
In order to clarify the molecular mechanism of the above-mentioned important processes, during the study, Lei Ming and Wu Jian's team used single-particle cryo-electron microscopy to analyze the complex structure of human telomerase holoenzyme, telomere DNA primer and RNA template hybrid double helix
.
Combining these structural information and the in-depth theoretical research of Li Guohui's team, it is found that the key amino acid Leu980 in the catalytic subunit of human telomerase plays a key role in controlling the length regulation of DNA-RNA hybrid double helix pairing
Related paper information: https://doi.
https://doi.
org/10.
1038/s41422-021-00586-7
