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    Home > Biochemistry News > Biotechnology News > Reveal the scientific principle of chemical methods for the preparation of stem cells.

    Reveal the scientific principle of chemical methods for the preparation of stem cells.

    • Last Update: 2020-08-10
    • Source: Internet
    • Author: User
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    After 5 years of research, the scientific research team led by the researcher of Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences, Yu Tingqing, revealed the scientific principle of the preparation of stem cells by chemical methods, developed a simple, efficient and standardized method for the preparation of stem cells, and provided a new scientific perspective and solution for inducing the research and optimization of the preparation path of pluripotent stem cells.
    research was published online in the early hours of April 6, Beijing time, in cell-stem cells.
    "This study has put our country in a world-leading position in the field of compound-induced pluripotent stem cells. Xie Xin, a researcher at the Shanghai Institute of Pharmaceutical Research of the Chinese Academy of Sciences and deputy director of the National Center for New Drug Screening, said the research method is significantly different from conventional induction methods, and that Brdu, a small molecule, is directly integrated into DNA to reshape the chromatin structure, thereby altering gene expression, which is a completely new mechanism.

    and this study greatly improves the efficiency of induction, so that chemical induction is expected to become a conventional method of inducing pluripotent stem cells.
    at the same time, this mechanism can guide scientists to design small molecules of compounds to change the chromatin structure, thereby optimizing the chemical-induced reprogramming system.
    is known that inducing pluripotent stem cells can help humans understand the mystery of cell "transformation" and provide a window for the scientific community to spy on the nature of life.
    multi-energy stem cells can also be used to regenerate new tissues and organs, providing "seed" cell sources for disease treatment and regenerative medicine.
    Japanese scientist and 2012 Nobel Prize winner in physiology or medicine, Yamanaka, uses viral vectors for gene transport, has potential cancer risks, and is at greater risk for future clinical applications.
    in order to induce somatic cells into pluripotent stem cells, scientists from various countries are constantly developing new methods. In the late
    , scientists used small chemical molecules to replace the yamayama elongation factor to induce pluripotent stem cells, but there are many steps, long time, low efficiency, mechanism is not clear and other shortcomings. After 5 years of efforts, the research team led by
    , yutse-ching, has developed an efficient and simple chemical small molecule-induced pluripotent stem cell method, known simply as CIP ,chemical inofplies, which is compound-induced stem cell pluripotentity.
    pointed out that the program only needs to give cells two different "potions" in turn "bath", so that the somatic cells can be "returned to the old child" to the stem cell state.
    this method is simpler, more efficient than the previous scheme and requires less initial cell volume.
    more importantly, it is possible to achieve a variety of somatic cell types " back to the child", including in vitro extremely difficult to cultivate liver cells.
    how these magical "magic potions" induce adult cells into the pluripotent stem cell state early in embryonic development? In individuals, all cells have the same chromatin, why form various forms and functions of various cells? It turns out that before the identifiable morphological changes occur, cells are constrained and differentiated in a specific direction, determining their future developmental fate.
    team study found that the fate of cells is controlled by the state of the "information hub" chromatin inside the nucleus. the sum of the open (1) and closed (0) states of the
    cell chromatin constitutes the state of destiny of the cell, which is like a computer binary "password string" that locks the cell in a specific state.
    because of the introduction of external genes, the method is simple to operate, the induction process conditions are uniform, all components are clear and standardized, will provide a safe and efficient preparation method for stem cell applications, with broad market application prospects.
    at the same time, it provides a new direction for opening up the fate of drug-induced cells, which will greatly promote the development of stem cells and regenerative medicine, and serve the medical and health undertakings of our country.
    co-authors of this research paper are Yu Endqing Researcher and Liu Jing Researcher.
    Cao Shangtao, Dr. Li Dongwei and Master Yu Shengyong of the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences are co-first authors of the thesis.
    research work has been supported by national key research and development projects, the Chinese Academy of Sciences, the National Natural Science Foundation, Guangdong Province and Guangzhou.
    .
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