Reveal the three-dimensional structure of stable chromatin and cell homeostasis mechanism of genome "useless" sequence for the first time

The non-coding sequences in the human genome play a vital role in a variety of biological processes, such as non-coding RNA, promoters, enhancers, and transposons

November 3, 2021, University of California, San Diego (UCSD) research group and Wang Wei Wei Wensheng Peking University research group in Science Advances on jointly published a report entitled Noncoding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability of Research paper.

The research is based on 5-kb resolution Hi-C data from 7 human normal cell lines and cancer cell lines (Rao et al.

Figure 1 Discovery of hub sites and high-throughput functional screening

The selected hub sites do not overlap with any protein-coding genes, non-coding RNAs and TADs, and 77.

Figure 2 Excision of the hub site results in simultaneous changes in the three-dimensional structure of chromatin and gene expression

Dr.

Link to the paper: https://