Revealing the immune regulation mechanism after brain injury provides a new target for improving the prognosis

The reporter learned on April 18 that the team of Professor Liu Qiang from the Department of Neurology, General Hospital of Tianjin Medical University, through research, revealed that the bone marrow hematopoietic system can sense signals from the damaged brain, generate regulatory immune cells, and go to the brain for rescue.

Stroke has now occupied the first place in the death rate of Chinese residents, and it is also the disease with the highest rate of disability in a single disease.

Liu Qiang's team analyzed bone marrow cells obtained by decompressive craniectomy in patients with cerebral hemorrhage and found that cerebral hemorrhage can quickly activate bone marrow hematopoietic stem cells.

In addition, the use of selective β3 adrenergic receptor agonists can promote the bone marrow to produce more monocytes with immunomodulatory function, thereby reducing neuroinflammation and improving the prognosis of cerebral hemorrhage.

This study revealed that acute brain injury represented by cerebral hemorrhage can activate the bone marrow hematopoietic system through innervation, and the effect of new monocytes on the prognosis of neuroinflammation and brain injury after the activation of the bone marrow hematopoietic system.