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    Home > Biochemistry News > Microbiology News > Reveals Chinese complex diseases between intestinal virlobes and complex diseases.

    Reveals Chinese complex diseases between intestinal virlobes and complex diseases.

    • Last Update: 2020-10-17
    • Source: Internet
    • Author: User
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    original title: Westlake University Zheng Weisheng team to reveal the Chinese the relationship between the intestinal bacteria and complex diseases

    in the human intestine, there is a large group of microorganisms invisible to the naked eye. Although they are "bacteria", but can coexist peacefully with human beings, and even play an important role in regulating human health, affecting the intake of nutrition, the ability to resist disease.

    we call it the gut bacteria.

    recent years, more and more studies have shown that a person's composition of the gut bacteria is different under different conditions of illness and health. So, is it the change of microorganisms that causes disease, or is it the change of microorganisms caused by disease? Microbes and diseases, who is the cause and who is the result?

    recently, the Zheng Yusheng Task Force at West Lake University made new discoveries on the interrelations between host genetics, gut microorganisms, and complex diseases in the Chinese group. For the first time, the study revealed the genetic variation points that affect Chinese groups of intestinal bacterios, found a causal relationship between some diseases and intestinal virlobes, and characterized the intestinal virlobes of dozens of complex diseases.

    This article was published in microbiome, a well-known journal in the field of microbiology, West Lake University 2018 ph.D. student Xu Fengxuan, postdoctoral student Fu Yuanqing as the co-first author of the paper, West Lake University, Dr. Zheng Yusheng, Sun Yat-sen University, Dr. Chen Yuming and dr. Wang Jun of the Institute of Microbiology of the Chinese Academy of Sciences are co-authors of this paper.

    . The host gene also affects the gut microbiome in the Microbiome journal Web Screenshot


    There is already more detailed and complete evidence that the composition or structure of the gut microbiome may be affected by the host's genetics. That is, because of our genes, the amount of certain gut bacteria in the body may be different. However, most of the studies that have been conducted have been conducted in European and American populations, and the correlation between gut microbes and cesodi genetic variation has not been clarified in Asian populations.

    there are considerable differences between different groups of people, both genetically and gut bacterial groups, so it is important to start research in the Asian population.

    in order to fill the gap in this field, Zheng Yusheng's task force and partners carried out a large-scale Chinese group queue study. They included about 4,000 middle-aged and elderly residents (45-75 years old), collected about 2,000 stool samples, and tested and analyzed the composition of their gut bacteria.

    to explore the causal relationship between intestinal bacterios and complex diseases at the population level, we must first reveal the genetic points that affect the bacterios. That is, we need to understand how the body's genes affect how much of the gut bacteria.

    team analyzed the entire genome-wide association of 203 gut microbiomes, first identifying that genetic genes can also affect certain gut microbiomes in Asian populations - our genes are different, and gut microbiomes are different.

    the discovery of a series of host genes that can influence changes in the gut bacteria, the team constructed a genetic risk score to evaluate the association between human genetic variation and the gut microbiota. The team then used a two-way Mendel randomization method to explore the causal relationship between gut microbes and dozens of complex human diseases or symptoms.

    Mendelian randomization is a method of using genetic variation as a tool variable in genetic epidemiological studies to investigate the causal relationship between exposure and results.

    analysis found that microbes and diseases do not simply define who is causing and who is causing. In different complex diseases, the intestinal bacterios are from time to time the cause, and from time to time, the case analysis is required.

    , for example, in East Asian populations, Saccharibacteria gate (one type of intestinal bacteri group, also known as TM7 door) can improve kidney function by affecting renal function biomarkers (i.e., creatinine and renal cymde filter rate). Here, the gut microbiotics are the cause.

    atrial fibrillation, chronic kidney disease and prostate cancer have a direct impact on the levels of some gut microorganisms. Here, the gut bacterios are fruits.

    the gut microbial characteristics of Parkinson's and colorectal cancer are similar!

    In addition to the causal association between some diseases and intestinal bacterios, the team also used unique intestinal microbial data to find that the characteristics of intestinal microbiomes corresponding to different complex diseases have their own uniqueness, but also have strong similarities.

    After unsecured clustering of disease risk scores based on microbial prediction, Zheng's team found similar gut microbial characteristics between Parkinson's and colorectal cancer, chronic granulocytic leukemia and systemic lupus erythematosus, and repeated the findings in a separate queue.

    . A series of original findings based on intestinal microbial prediction

    and a series of original findings based on the Chinese group have laid the foundation for an in-depth understanding of the causal link between intestinal bacteriobioty and complex diseases, and the characteristic analysis of different disease-like bacterios and special bacterios may help scientists understand the relationship and pathogenesis of complex diseases in humans and provide inspiration for further development of new drugs.


    Xu FZ, Fu YQ, Sun TY, Jiang ZL, Miao ZL, Shuai ML, Gou WL, Ling CW, Yang J, Wang J, Chen YM, Zheng JS. The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases. Microbiome 2020,8,145.

    source: Westlake University

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