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Rice stripe virus (RSV) is a kind of insect-borne micro-virus, mainly transmitted by meso-insect ash lice in a long-lasting, proliferative way, resulting in serious crop reduction in Southeast Asia, such as rice.
July 18, Cui Feng's research team at the Institute of Zoology of the Chinese Academy of Sciences published a research paper entitled The c-Jun N-Terminal Kinase Pathway of a vector insect is activated by virus capsid protein and promotes viral replication in the international journal eLife, making new progress in the study of RSV interactions with meso-insects.
studies have found that RSV's crust protein CP competitively binds to the G protein path inhibitor II (GPS2) of grey fly lice, reducing the inhibition of GPS2 on JNK-activated compounds, thus improving JNK phosphorylation levels.
, the virus also improves the expression of TNF-alpha, the tumor necrotum causer that swims on the JNK signal pathway, and reduces the expression of GPS2.
the increase in JNK phosphorylation levels increases the proliferation of RSV in insects, and by interfering with the expression of the JNK gene or using JNK-activated inhibitors, the proliferation of RSV in insects is inhibited and the onset of plants is delayed.
the results of this study reveal the key role of JNK signal path in the process of virus replication, which provides a new way to control the spread of RSV in the future.
Cui Feng's team has long been engaged in the study of meso-virus-plant molecular interoperability, focusing on revealing the key role of meso-insects in the transmission of viruses, and has published a number of relevant results in several important academic journals in the field.
the study was jointly conducted by Cui Feng and Chinese Academy of Sciences academician Kang Le, with Cui Feng and He Le as co-authors, Postdoctoral Wang Wei, Assistant Researcher Zhao Wan and Ph.D. student Li Jing as co-authors.
the research was funded by the Chinese Academy of Sciences Strategic Pilot Science and Technology Special Class B, the Ministry of Science and Technology "973" and so on.
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