Reverse aging! Recoverable telomere length method found

A U.S. research team has made a breakthrough in anti-aging research by sifting through more than 100,000 known chemicals and successfully discovering small molecules that restore telomere length in mice, Sciencedirect Science News reported Sunday. The study was published in the journal Cell Stem Cells.
at this stage, most of human anti-aging research is focused on the "small hat" at the end of chromosomes, telomeres, which prevent the "wear" of genetic DNA code and are critical in the process of biological health and aging. But each time cells divide, they become shorter until the cells no longer divide and die. If this process can be interfered with, it will achieve the regulation of the adverse effects of aging and aging.
In 2015, scientists discovered a gene called PARN that stands out in telomerase because it stabilizes TERC, an important component of telomerase, as normal;
This time, researchers at Harvard University and Boston Children's Hospital screened more than 100,000 known chemicals to find compounds that protect PARN's health function, and found that this could be achieved by inhibiting an enzyme called PAPD5, which effectively affects TERC and restores normal balance of telomerase.In the
lab, the team first tested the compounds using stem cells made from cells from patients with congenital horning disorders and found that the compounds improved TERC levels in stem cells, and then used human blood stem cells to trigger mutations in the PARN gene, which were then implanted in mice treated with the compound. They found that the treatment restores the telomere length of stem cells without any adverse effects on animals.
researchers hope to use the compound to develop a new class of oral drugs for whole-body stem cells that could play a role in treating diseases caused by aging and even addressing the broader human anti-aging problem.