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Rheumatology: Serum cholesterol loading capacity of macrophages in RA patients is regulated by seropositivity and C-reactive protein

 Last Update: 2022-08-15
 Source: Internet
 Author: User

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Objective: Excessive accumulation of cholesterol in macrophages is a key step in the formation of atherosclerotic plaqu.

Cholesterol Excessive AccumulationCholesterol Excessive Accumulation Cluster Rheumatoid Arthritis (RA) Cholesterol Loading Capacity (CLC) Cholesterol Loading Capacity (CLC)

Methods: In a cross- sectional observational cohort of 104 RA patients, intracellular cholesterol content in CLCs as human THP-1-derived macrophages was determined after incubation with patient ser.

Cross-sectional observation queue

Results: OxPL-apoB100, anti-oxLDL-IgG and PCSK9 were positively correlated with CLC (all p < 02

CONCLUSIONS: Oxidized low-density lipoprotein can directly affect CLC in double-seropositive RA patients

Oxidized low-density lipoprotein can directly affect CLC in patients with double seropositive .

Source:

Karpouzas GA, Papotti B, Ormseth SR, et .

Karpouzas GA, Papotti B, Ormseth SR, et .
Serum cholesterol loading capacity on macrophages is regulated by seropositivity and C-reactive protein in rheumatoid arthritis patients [published online ahead of print, 2022 Jul
Rheumatology (Oxfor.
2022; keac39 doi:11093/rheumatology/keac394 leave a message here

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