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    Home > Biochemistry News > Biotechnology News > Ring RNA has the function of translating proteins.

    Ring RNA has the function of translating proteins.

    • Last Update: 2020-09-04
    • Source: Internet
    • Author: User
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    A few years ago, scientists discovered a new type of RNA molecule, which, unlike other function-known RNAs, forms a closed loop and is known as ring RNA.
    although we know very little about them, the number of these molecules can be high, especially in the brain, which accumulates with age.
    , ring RNA was previously thought to be responsible for other things in cells, as opposed to mRNAs with protein-making messages.
    , however, a team of scientists, led by Sebastian Kadener, an associate professor at the Hebrew University of Jerusalem, led by Israel and Germany, found that ring RNA has the function of translating proteins.
    , they also found that these RNA molecules play a significant role in brain cells.
    to confirm the translational function of ring RNA, the researchers used Drosophila as an experimental subject, as well as technologies that fuse molecular biology, computational biology, and neurobiology.
    results show that specific ring RNA molecules bind to the nucleosome responsible for making the proteins, and also find the translated proteins.
    They further found that they were associated with specific locations in cells, especially on synapses (the link points between two nerve cells), such as fruit flies, which respond to specific signals when food sources are cut off for up to 12 hours.
    addition to hunger, another cause of ring RNA is aging, leading to speculation that they also play a place in neurodegenerative diseases.
    is there such speculation? In addition to the aging mentioned above, another evidence is that Professor Kadener found that the transliterated ring RNA is made from a gene called Muscleblind, which, if defective in its function, can lead to a neurodegenerative disease called myotonic dystrophy.
    the disease is better in adulthood, patients gradually muscle weakness, and the blind muscle gene plays the role of regulating ring RNA.
    the latter's number in the brain and the mechanism of translation, it is natural to infer that there is a significant correlation between cyclic RNA and muscular dystrophy.
    , according to Professor Kadener, he believes that by identifying the function of ring RNA, we can refine our understanding of molecular biology and help us understand aging or neurodegenerative diseases.
    National RNA is not the only scientist involved in the study who is sure of the importance of ring RNA, said Gil Ast, a professor at Tel Aviv University's Shackler School of Medicine who was not involved in the current study, but he remains positive: "Kadener's team found that ring RNA may have been translated into synapses in the brain.
    is an important start in finding the function of unknown RNA, as it shows a link between ring RNA and brain-related diseases.
    Now, researchers want to explore whether ring RNA also involves age-related diseases and analyze their translation mechanisms, which may give us a better understanding of how central transliteration plays in cells.
    .
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