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Correct repair of damaged DNA is essential for genome integrity and ontogeny
Sun Qianwen’s laboratory has previously found that by maintaining the level of the three-stranded genome structure R-loop, plastids can be protected from genome breaks caused by transcription-replication collisions (The Plant Cell, 2017; Cell Reports, 2020).
Figure 1: (A) The recombinase RecA1 is distributed in filaments in the chloroplast, but the accumulation of RNA:DNA hybrids (in the atrnh1c mutant) leads to its punctate distribution;
(B) RNA:DNA hybrids mediate the molecular mechanism model of chloroplast genome damage repair
It is reported that this study was published in the "Nucleic Acids Research" magazine on June 16, 2021 with "RNase H1C, single-stranded DNA binding protein WHY1/3 and recombinase RecA1 in Arabidopsis chloroplasts to complete DNA damage repair.
Original link: https://academic.