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    Home > Biochemistry News > Biotechnology News > Rodents or asymptomatic carriers of SARS-like coronavirus

    Rodents or asymptomatic carriers of SARS-like coronavirus

    • Last Update: 2022-01-12
    • Source: Internet
    • Author: User
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    Science and Technology Daily, Beijing, November 23 (intern reporter Zhang Jiaxin) According to a study published in the latest issue of "Public Science Library Computational Biology", some ancestral rodents may be repeatedly infected with SARS-like coronaviruses, causing them to be against pathogens.
    Tolerance or resistance developed

    .
    Researchers say this increases the possibility that modern rodents may be hosts for SARS-like viruses

    .

    The new coronavirus originates from a zoonotic disease.
    Previous studies have shown that horseshoe bats are the host of many SARS-like viruses.
    They are tolerant to these viruses and do not show extreme symptoms

    .
    Identifying other animals with tolerance mechanisms to coronaviruses is very important for understanding the potential virus pool that may transmit new pathogens to humans

    .

    It is known that coronaviruses enter cells through the ACE2 receptor
    .
    In this new study, researchers from Princeton University in the United States conducted an evolutionary analysis of the virus's ACE2 receptor across mammalian species

    .
    Primates have a highly conserved amino acid sequence at the ACE2 receptor site

    .
    However, rodents are more diverse and faster to evolve at these sites

    .

    In general, in the evolutionary history of primates, SARS-like coronavirus infection is not the driving force for their evolution, but some rodents are likely to be repeatedly infected by SARS-like coronaviruses during a long period of evolution.
    These infections have acquired a certain degree of tolerance or resistance to these coronaviruses

    .
    Studies have shown that some modern rodent species, or including some species that have not yet been discovered, are likely to be asymptomatic carriers of SARS-like coronaviruses

    .

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