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    Home > Biochemistry News > Biotechnology News > Rodents or asymptomatic carriers of SARS-like coronavirus

    Rodents or asymptomatic carriers of SARS-like coronavirus

    • Last Update: 2022-01-12
    • Source: Internet
    • Author: User
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    Science and Technology Daily, Beijing, November 23 (intern reporter Zhang Jiaxin) According to a study published in the latest issue of "Public Science Library Computational Biology", some ancestral rodents may be repeatedly infected with SARS-like coronaviruses, causing them to be against pathogens.
    Tolerance or resistance developed

    Researchers say this increases the possibility that modern rodents may be hosts for SARS-like viruses


    The new coronavirus originates from a zoonotic disease.
    Previous studies have shown that horseshoe bats are the host of many SARS-like viruses.
    They are tolerant to these viruses and do not show extreme symptoms

    Identifying other animals with tolerance mechanisms to coronaviruses is very important for understanding the potential virus pool that may transmit new pathogens to humans


    It is known that coronaviruses enter cells through the ACE2 receptor
    In this new study, researchers from Princeton University in the United States conducted an evolutionary analysis of the virus's ACE2 receptor across mammalian species

    Primates have a highly conserved amino acid sequence at the ACE2 receptor site

    However, rodents are more diverse and faster to evolve at these sites


    In general, in the evolutionary history of primates, SARS-like coronavirus infection is not the driving force for their evolution, but some rodents are likely to be repeatedly infected by SARS-like coronaviruses during a long period of evolution.
    These infections have acquired a certain degree of tolerance or resistance to these coronaviruses

    Studies have shown that some modern rodent species, or including some species that have not yet been discovered, are likely to be asymptomatic carriers of SARS-like coronaviruses


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