RXEG1: A new mechanism for plants to identify pathogens and activate autoimmune infections.

Plant war pathogen, who will sound the "concentration number"? A new study by the Crop Disease Team at Nanjing Agricultural University found that the key defense "first-level sentinel" , RXEG1. On February 9,
, the team published a study in Nature Communications, noting that RXEG1 is a key factor in plant identification of disease bacteria, and reveals new mechanisms for plant strain-identification and autoimmune activation.
a year ago, the team published a study in the American journal Science, noting that when the bacteria attack plants, it can lead to a "decoy mode" (DECOY), that is, the disease mold in the early days of the invasion of plants, by secreting sugar-based hydrolysis XEG1 To attack the plant cell wall, the plant by inhibiting the protein GIP1 to XEG1 defense process, the disease bacteria also evolved XEG1 enzyme loss mutant XLP1, as a "molecular bait" to competitively interfere with GIP1, cover XEG1 attacks on plants.
now, there's a new "sequel" to the research story surrounding the plant's war pathogen, which has successfully revealed how plants recognize XEG1 and activate autoimmune responsemechanisms.
the study systematically analyzed more than 400 encoded cell membranes in the tobacco genome rich in leucine repeating (LRR) receptors, and established a set of high-throughput analysis system of plant LRR receptor function based on viral induced gene silencing technology, and successfully identified the receptor protein RXEG1 in plants to identify the disease-like pattern molecule XEG1.
later found that RXEG1 is a key factor in the production of cell necrosis and defensive response after plant recognition of XEG1, and activating RXEG1 can significantly improve plant resistance to disease bacteria.
the first author of the paper, Dr. Wang Yan, a young teacher at Nanjing Agricultural University's School of Plant Protection, gave reporters a metaphor, RXEG1 is like the "outpost" of the campaign, it is activated, will be the first time to blow the plant war disease bacteria defense "assembly number", immediately stimulate the crop resistance signal, the full start of the crop anti-epidemic emergency mechanism.
Wang Yan told reporters that RXEG1 can identify different mold and fungus secretion of the pathogenic factor XEG1 family protein, indicating that this "sentinel" has a strong "applicability", that is, as an immune receptor can regulate the plant's broad-spectrum resistance to different pathogens. Wang Yuanchao, a
paper communication author and professor at the School of Plant Protection at Nanjing Agricultural University, told reporters that the study established an efficient and accurate positioning system for crop immune receptors, solved the technical barriers of scientists to "find a needle in a haystack" in the past, helped to quickly identify key immune receptors in different crops, and accelerated the exploitation and utilization of crop disease-resistant resources, thereby reducing the use of pesticides and effectively improving the economic and social effects of crops.
Professor Dong Sharman of the Crop Disease Team at Nanjing Agricultural University, Associate Professor Ye Wenwu, and Professor Brett Tyler of Oregon State University in the United States were also involved in the study.
the research has been supported by the National Natural Science Foundation of China, public welfare industry research projects.
it is understood that the crop disease research team of Nanjing Agricultural University, with the goal of developing high-efficiency prevention and control strategies and techniques for crop diseases, has long focused on the pathogenic and mutation mechanisms of important crop disease bacteria, and has made a series of important progress in Science, Biology, Nature Communications, and has made a series of important progress in Science, Biology, Nature Communications. Plant Cell, PLoS Pathogens and other international academic journals published more than 140 research papers, cited by international peers more than 3000 times, its revealed new mechanism of pathogenic disease "bait model" was selected in 2017 China's top ten universities and scientific and technological progress.
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