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    Home > Biochemistry News > Biotechnology News > Salk researchers have revealed that cell reaction systems can accurately distinguish between DNA damage and exogenous DNA damage.

    Salk researchers have revealed that cell reaction systems can accurately distinguish between DNA damage and exogenous DNA damage.

    • Last Update: 2020-08-06
    • Source: Internet
    • Author: User
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    Every organism in nature protects its OWN DNA at any cost, but how cells accurately distinguish between damage to their own DNA or damage to viral exogenous DNA remains a mystery, and in a recent study published in the international journal Cell, researchers from the Salk Institute have revealed the mechanism by which cell response systems accurately distinguish between the two threats, and research or help develop new types of cancer-selective viral therapy can also help understand why aging and certain diseases seem to be open.
    researcher Professor Clodagh O'Shea said the study sheds light on a basic mechanism for the body to distinguish between DNA fractures in cells and viral genomes to induce different host-protected immune responses, and the study could help explain why specific conditions such as aging, chemotherapy for cancer, and inflammation make our body more sensitive to viral infections.
    many factors cause DNA fractures, and the researchers explain how a series of proteins called MRN complexes detect DNA and virus ruptures and amplify this effect through histones;
    generally speaking, a common DNA virus enters the nucleus of the host cell and initiates the expression of the gene that replicates its own DNA, while the host cell detects this unauthorized replication, and the MRN complex selectively neutralizes the virus's DNA under the precursor, which does not induce a wide range of cell-killing reactions, and mrN's response to the virus stays locally and only selectively suppresses the virus;
    , the researchers developed a new virus that can be destroyed in normal cells, but can replicate specifically in cancer cells, unlike normal cells, which almost always contain high levels of DNA damage, in which MRN may react to DNA rupture, but engineered viruses may escape surveillance.
    cancer cells always have a high mutation rate and genomic instability at an early stage, so we can imagine how difficult it is to build a virus to destroy early body damage and as a precautionary measure.
    DNA-related information: On January 11, local time, the Cold Spring Harbor Laboratory in the United States announced the dishonoroft of james Watson, the father of DNA.
    Watson said in a Documentary that aired on PBS on January 2nd that the IQ differences between blacks and whites are genetically inherited. James Watson, an American scientist who
    Nobel Prize-winning scientist and one of the discoverers of the double-helix structure of DNA known as the "father of DNA" in the world, has been stripped of his honorary title for his frequent comments about differences in intelligence among races.
    , as a leading scholar in genetic science, Watson mentioned in the television program the idea that whites and African-Americans have genetically induced differences in average IQ, the BBC reported Wednesday.
    in a popular science documentary, Watson made that point.
    on Friday, Watson's Cold Spring Harbor Laboratory (CSHL), which he led from 1968 to 1993, issued a statement saying it would be stripped of the honorary title previously awarded to him.
    , cold spring port labs said in a statement that it strongly disagrees with Watson's remarks and dismisses them as "completely unscientific."
    Watson has made similar statements several times before.
    2007, he told the Sunday Times that he was pessimistic about Africa's future because "all social policies about Africa's development are based on the same level of IQ as they (Africans) and us (whites), but all the scientific tests have proved that to be incorrect."
    ", he added, that while he subjectively wanted everyone to be born equal, "those who have to deal with black employees know it's not true."
    " Cold Spring Harbor Laboratory revoked all of Watson's executive duties after making similar statements, but retained his honorary title for the time being because Watson later apologized.
    However, in a documentary that aired on January 2 this year, he publicly stated that "his views have not changed".
    in view of this, cold spring port laboratory finally decided to deprive him of his title.
    Source: Decoding Medicine, Red Business Network.
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