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    Home > Biochemistry News > Biotechnology News > Say goodbye to needle pain! After the "turtle" pills, oral insulin has a new breakthrough

    Say goodbye to needle pain! After the "turtle" pills, oral insulin has a new breakthrough

    • Last Update: 2020-06-08
    • Source: Internet
    • Author: User
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    Recently, MIT engineers worked with scientists at Novo Nordisk to design a new drug capsule that can carry insulin or other protein drugsThis means that insulin injections may become the past, and more than 100 million people around the world who live on insulin can say goodbye to needle painThe findings were published recently in the journal Nature MedicineDOI: 10.1038/s41591-0598-9
    MIT Professors DrRobert Langer and Professor Giovanni Traverso have developed several new oral administration strategiesIn previous studies, they found a practical way to wrap small needles of effective drugs into star-shaped structures in pills that could stay in the stomach for days to weeksearlier this year researchers developed a nail cap-sized capsule containing a small needle made from compressed insulinWhen the capsule reaches the stomach, the needle injects the drug into the stomach walloral insulin capsule diagram Picture: ReferenceThe transition to the small intestinehowever, injecting insulin into the stomach creates a sense of pain, which is not the effect the researchers want to achieveSo Professor Traverso set his sights on the small intestineMost of the drugs are absorbed through the small intestine, first because the surface area of the small intestine is very large (250m2, about the size of a tennis court), and the other is the lack of pain receptors in the small intestineTherefore, it is theoretically feasible to choose painless micro-injection in the small intestinein order to get the capsule to reach the small intestine and inject it slightly, the researchers applied a polymer to the capsule that could remain in an acidic environmentWhen the capsule reaches the small intestine, the higher the pH, the more the capsule will rupture and the capsule's three folding arms will pop openmicroneedles onfolding arms Picture: Reference s1
    each folding arm has a small 1 mm long microneedle that can carry insulin or other medicationsWhen the folding arms are open, they release forces that allow tiny microneedles to penetrate the outermost layer of the small intestine tissueworried about intestinal blockage? Non-existentthe needle dissolves and releases the drug after the injectionThe folding arm was also designed by researchers to reduce the risk of intestinal blockage, which breaks after completing its missionin pig tests, researchers showed that the 30 mm capsule effectively delivers insulin and immediately produces a hypoglycemic reactionThey also showed that after microneedle injections, there was no blockage in the intestineand and the folding arm was safely drained"We are very pleased with the latest results of the new oral administration devices developed by our laboratory members and partners, and we look forward to providing assistance to people with diabetes and other patients in the future," said DrRobert Langer,new advances in other "oral insulins"this is not the first time oral insulin has been reported, following a report in the journal Science that scientists have developed a special "capsule" that can inject insulin into the lining of the stomach2018, the team published a paper in the journal PNAS revealing a possibility: wrapping insulin in a special liquid that has the same viscosity as honeythese innovative technologies can take years to complete safety and efficacy testsBut once approved, it will break a "hundred-year gap" and open up new treatment options for countless patients : [1] A luminal unfolding microneedle injector for oral delivery of macromolecules [2] New capsule can orally deliver drugs that usually have to be injected [3] ""? Science: Research and development inspired by tortoises
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