Sci Adv: A new strategy for immune "cocktail" therapy against cancer.

October 2, 2020 /--- Immune checkpoint therapy has shown potential in the treatment of a variety of tumors, but adverse reactions limit their further application.
that although scientists have developed combination therapies to enhance the effectiveness of the immunotherapy, there has been no satisfactory tumor suppression in various tumor models.
recently, a research team led by Professor Tian Huayu of the Changchun Institute of Applied Chemistry of the Chinese Academy of Sciences proposed an innovative immuno-cocktail therapy that combines immuno-checkpoint therapy with other treatments.
several enhancements in cancer immunotherapy through the use of nano-delivery systems.
the study was published September 30 in the journal Science Advance.
(Photo Source: CIAC) The cocktail therapy achieves anti-tumor therapy by combining immunogenic chemotherapy, immunochemical checkpoint blocking, and extracellular substation elimination.
it consists of two tumor micro-environment (TME) response drugs and nanoparticle vectors.
intelligent nano-delivery systems enable amycin-specific delivery, as well as co-delivery of shRNA that inhibits PD-L1 and the expression of hyalurase in the tumor area, improving treatment effectiveness.
cocktail therapy can also promote the activation of T cells by inducing the death of tumor immunogenic cells and changing the microenvironment of immunosuppressive tumors.
benefit from these benefits, and the therapy achieves excellent immunotherapy results among a wide range of tumor types.
, for example, cocktail therapy has caused significant tumor shrinking in B16F10, CT26 and 4T1 tumor models, making it more effective than traditional combinations of chemotherapy and immunochemical test therapy.
Said: "These excellent results are mainly due to an increase in cd8 plus T cell immersion in the tumor, which can also induce strong immune memory effects and effectively prevent tumor metastasis."
" work proposes a promising comprehensive immunotherapy strategy that integrates multiple aspects of the cancer-immune cycle, such as tumor antigen release, transport from the periter to tumor T cells, effectively killing tumor cells and the production of immune memory T cells.
cocktail therapy strategy provides a new technology that can be combined with immuno-checkpoint therapy.
is a way to clinically develop more effective anti-tumor immunotherapy.
( Bioon.com):Scientists propose immune cocktail therapy to boost cancer-immunity cycle in multiple aspects:An immune cocktail therapy to realize multiple boosting of the cancer-immunity cycle by combination of drug/gene delivery nanoparticles" Science Advances (2020). DOI: 10.1126/sciadv.abc7828.