Sci Adv: Chen Xuesi's team develops immuno-cocktail therapy with a tumor reduction rate of up to 97.3%

Immuno-checkpoint inhibitors are a promising cancer immunotherapy, but in many tumors, low response rates limit their further application.
although scientists have developed combination therapies to enhance the effectiveness of immuno-checkpoint inhibitors, these treatments have not produced good tumor suppression in many tumor models.
September 30, Science Advances published a study by a team of researchers from the Chun Institute of Applied Chemistry of the Chinese Academy of Sciences, who developed a new type of immuno-cocktail therapy and developed a nano-delivery system that matches the cocktail therapy.
this new therapy has achieved several enhancements in the cancer immunology cycle, producing excellent immunotherapy results in different mouse tumor models.
cancer immunocirculation, a concept proposed in 2013 by two U.S. scientists, Daniel S. Chen and Ira Mellman, begins with the release of antigens by tumor cells and ends with the killing of tumor cells.
this concept explains the mechanism by which the immune system kills tumor cells.
In this study, researchers developed immuno-cocktail therapy that integrates multiple aspects of the cancer immunologic cycle, such as the release of tumor antigens, the migration of T-cells from exostation to tumor tissue, the effective killing of tumor cells, and the production of immune memory T-cells.
specifically, this cocktail therapy consists of two tumor micro-environment (TME) response drugs and carrier nanoparticles, combining chemotherapy, immuno-checkpoint suppression, and extracellular substation degradation.
intelligent nano-delivery systems enable specific delivery of doxorubicin, a chemotherapy drug, and co-delivery of PD-L1 and hyalurase shRNA protons in tumor areas to improve treatment.
immuno-cocktail therapy (Source: Science Advances) This cocktail therapy can also promote T-cell initiation by inducing tumor immunogenic cell death and polarizing TME from immunosuppressive polarization to immune activity.
immuno-cocktail therapy can induce immunoactive TME (Source: Science Advances) Treatment results in a variety of tumor models show that this cocktail therapy is more effective than traditional chemotherapy combined with immuno-checkpoint inhibitors, which can significantly reduce tumors.
, in mouse melanoma models, the cocktail therapy group showed the most effective tumor suppression, with 97.3 percent of tumors shrinking, and 5 out of 6 mice experienced partial remission (PR), suggesting that cocktail therapy improved overall remission rate (ORR).
The subsurfacial treatment of melanoma mouse models (Source: Science Advances) "This is mainly due to an increase in peri-tumor CD8-T cell immersion, which induces strong immune memory effects and effectively prevents tumor metastasis."
," Explains Professor Tian.
may affect the mechanisms surrounding T-cell immersion (Source: Science Advances) In general, the immuno-cocktail therapy proposed in this study is a promising treatment strategy that is important for the development of more effective anti-tumor immunotherapy.
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