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    Home > Active Ingredient News > Study of Nervous System > Sci Adv: New technology can repair brain cell damage after stroke

    Sci Adv: New technology can repair brain cell damage after stroke

    • Last Update: 2021-04-28
    • Source: Internet
    • Author: User
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    News from March 21, 2021 //---Most stroke victims are not treated quickly enough to prevent brain damage.
    Scientists at Ohio State University Wexner Medical Center, School of Engineering, and School of Medicine have developed techniques to "retrain" cells to help repair damaged brain tissue.
    Even if taken a few days after an ischemic stroke, this improvement could one day help patients restore speech, cognitive, and motor functions.

    Engineering and medical researchers use a process called tissue nanotransfection (TNT) created by Ohio State University to introduce genetic material into cells.
    This allows them to reprogram the skin cells to make them different (that is, they can be transformed into vascular cells) to help repair damaged brain tissue.

    (Image source: www.
    pixabay.
    com)

    The results of the study were published online today in the journal Science Advance.
    In this mouse study, cells have been "pretreated" with specific genes and injected into the brain affected by stroke, where they promote the formation of new blood vessels through reprogramming and repair of damaged brain tissue.
    Daniel Garrigo Perez, assistant professor of biomedical engineering and surgery at Ohio State University, said: “We can rewrite the genetic code of skin cells to make them blood vessel cells.
    When they are deployed into the brain, they can grow out.
    New healthy blood vessel tissue to restore normal blood supply and help repair damaged brain tissue.
    "
    Researchers studied this process in mice and found that mice treated with this innovative cell therapy recovered 90% of their motor function.
    MRI scans showed that the damaged areas of the brain were repaired within a few weeks.
    Co-author Natalia Higuita Castro, assistant professor of biomedical engineering, said: "We found that mice have a higher recovery capacity, because the cells injected into the affected area also release healing signals in the form of vesicles, which help restore damaged brain tissue.
    "
    Stroke is the second leading cause of death in the world, and survivors often suffer irreversible brain damage, which leads to paralysis, language barriers and loss of motor function.
    There is no treatment that can solve the persistent and debilitating damage to brain tissue caused by stroke.
    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003







    (Image source: www.
    pixabay.
    com)

    The results of the study were published online today in the journal Science Advance.
    In this mouse study, cells have been "pretreated" with specific genes and injected into the brain affected by stroke, where they promote the formation of new blood vessels through reprogramming and repair of damaged brain tissue.
    Daniel Garrigo Perez, assistant professor of biomedical engineering and surgery at Ohio State University, said: “We can rewrite the genetic code of skin cells to make them blood vessel cells.
    When they are deployed into the brain, they can grow out.
    New healthy blood vessel tissue to restore normal blood supply and help repair damaged brain tissue.
    "
    Researchers studied this process in mice and found that mice treated with this innovative cell therapy recovered 90% of their motor function.
    MRI scans showed that the damaged areas of the brain were repaired within a few weeks.
    Co-author Natalia Higuita Castro, assistant professor of biomedical engineering, said: "We found that mice have a higher recovery capacity, because the cells injected into the affected area also release healing signals in the form of vesicles, which help restore damaged brain tissue.
    "
    Stroke is the second leading cause of death in the world, and survivors often suffer irreversible brain damage, which leads to paralysis, language barriers and loss of motor function.
    There is no treatment that can solve the persistent and debilitating damage to brain tissue caused by stroke.
    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003




    (Image source: www.
    pixabay.
    com)

    The results of the study were published online today in the journal Science Advance.
    In this mouse study, cells have been "pretreated" with specific genes and injected into the brain affected by stroke, where they promote the formation of new blood vessels through reprogramming and repair of damaged brain tissue.
    Daniel Garrigo Perez, assistant professor of biomedical engineering and surgery at Ohio State University, said: “We can rewrite the genetic code of skin cells to make them blood vessel cells.
    When they are deployed into the brain, they can grow out.
    New healthy blood vessel tissue to restore normal blood supply and help repair damaged brain tissue.
    "
    Researchers studied this process in mice and found that mice treated with this innovative cell therapy recovered 90% of their motor function.
    MRI scans showed that the damaged areas of the brain were repaired within a few weeks.
    Co-author Natalia Higuita Castro, assistant professor of biomedical engineering, said: "We found that mice have a higher recovery capacity, because the cells injected into the affected area also release healing signals in the form of vesicles, which help restore damaged brain tissue.
    "
    Stroke is the second leading cause of death in the world, and survivors often suffer irreversible brain damage, which leads to paralysis, language barriers and loss of motor function.
    There is no treatment that can solve the persistent and debilitating damage to brain tissue caused by stroke.
    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003




    In this mouse study, cells have been "pretreated" with specific genes and injected into the brain affected by stroke, where they promote the formation of new blood vessels through reprogramming and repair of damaged brain tissue.
    Daniel Garrigo Perez, assistant professor of biomedical engineering and surgery at Ohio State University, said: “We can rewrite the genetic code of skin cells to make them blood vessel cells.
    When they are deployed into the brain, they can grow out.
    New healthy blood vessel tissue to restore normal blood supply and help repair damaged brain tissue.
    "
    Researchers studied this process in mice and found that mice treated with this innovative cell therapy recovered 90% of their motor function.
    MRI scans showed that the damaged areas of the brain were repaired within a few weeks.
    Co-author Natalia Higuita Castro, assistant professor of biomedical engineering, said: "We found that mice have a higher recovery capacity, because the cells injected into the affected area also release healing signals in the form of vesicles, which help restore damaged brain tissue.
    "
    Stroke is the second leading cause of death in the world, and survivors often suffer irreversible brain damage, which leads to paralysis, language barriers and loss of motor function.
    There is no treatment that can solve the persistent and debilitating damage to brain tissue caused by stroke.
    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    : K.
    Rakhra el al.
    ,sciencemag.
    org/content/7/12/eabd4735"> "Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look … 6/sciimmunol.
    abd8003



    ··:“,。,,,。”
    ,90%。 MRI。
    ,Natalia Higuita Castro:“,,。”
    ,,,。。
    ,。80%,,。
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003

    Researchers studied this process in mice and found that mice treated with this innovative cell therapy recovered 90% of their motor function.
    MRI scans showed that the damaged areas of the brain were repaired within a few weeks.
    Co-author Natalia Higuita Castro, assistant professor of biomedical engineering, said: "We found that mice have a higher recovery capacity, because the cells injected into the affected area also release healing signals in the form of vesicles, which help restore damaged brain tissue.
    "
    Stroke is the second leading cause of death in the world, and survivors often suffer irreversible brain damage, which leads to paralysis, language barriers and loss of motor function.
    There is no treatment that can solve the persistent and debilitating damage to brain tissue caused by stroke.
    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003


    Co-author Natalia Higuita Castro, assistant professor of biomedical engineering, said: "We found that mice have a higher recovery capacity, because the cells injected into the affected area also release healing signals in the form of vesicles, which help restore damaged brain tissue.
    "
    Stroke is the second leading cause of death in the world, and survivors often suffer irreversible brain damage, which leads to paralysis, language barriers and loss of motor function.
    There is no treatment that can solve the persistent and debilitating damage to brain tissue caused by stroke.
    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003


    Stroke is the second leading cause of death in the world, and survivors often suffer irreversible brain damage, which leads to paralysis, language barriers and loss of motor function.
    There is no treatment that can solve the persistent and debilitating damage to brain tissue caused by stroke.
    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003

    Although advances in medicine have allowed doctors to clear blood clots in the brain faster and improve outcomes, this is only effective before brain tissue dies within a few hours after a stroke.
    About 80% of patients with ischemic stroke do not receive clot removal therapy in time to prevent permanent defects in their speech, cognitive and motor functions.
    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003

    Dr.
    Shahid Nimjee, a neurosurgeon at Ohio State University's Wexner Medical Center and a member of the Ohio State University Institute of Neurology, said: "We are now understanding that there may be opportunities for regenerative cells to restore brain function.
    " Researchers continue to study this.
    Methods, and they are also exploring other potential uses of the technology in the treatment of brain diseases such as Alzheimer’s and autoimmune diseases.
    (Bioon.
    com)
    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003

    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003

    Source of information: com/news/2021-03-technology-retrains-cells-brain-tissue.
    html">New technology'retrains' cells to repair damaged brain tissue in mice after stroke

    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003


    Original source: K.
    Rakhra el al.
    , sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology (2021).
    immunology.
    sciencemag.
    org/look… 6/sciimmunol.
    abd8003
    Original source: sciencemag.
    org/content/7/12/eabd4735">"Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells," Science Immunology
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