Sci Adv: Reveals the molecular mechanism by which transons regulate neuron differentiation and nerve transfer activity in the human brain.

September 10, 2020 // -- The human gene contains more than 4.5 million DNA components called transontrovirals, virus-like components that jump through the genome and help regulate gene expression, which can be done by binding to transcription factors, a special protein that regulates DNA transcription as RNA, which affects gene expression in a wide range of biological events.
a recent study published in the international journal Science Advances, scientists from institutions such as the Federal Institute of Technology in Lausanne found that transposables play a crucial role in affecting brain development in humans.
Photo Source: Pixabay/CC0 Public Domain Researchers have found that transposes can regulate brain development by "collaborating" with two specific proteins from a specific protein family called KZF As early as 2019, researchers discovered the regulatory activity of transposes in the first few days of life, but they speculated that these regulatory sequences would then be rekindled to regulate the development and function of the organs.
the researchers identified two types of KZFPs that may be specific to primates only, and that they can also be expressed in specific areas of the brain and adult brains in human development, and after further study, the researchers found that these proteins may be able to control the activity of the rotor, at least This is true in neurons and laboratory-cultured brain-like organs, so these two KZFPs affect the differentiation and neurotranstractability of neurons and protect these cells from inflammatory reactions that may trigger an inflammatory response if their target transsegots are retained for expression.
Final researcher Didier Trono said the results of this paper reveal how two proteins that have only recently emerged in evolution shape the human brain by promoting the selection of reinstates, and that these viral "entities" may have been reshaping the genomes of our ancestral bodies from the start.
original source: Priscilla Turelli, Christopher Playfoot, Dephine Grun, et al. Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons, Science Advances (2020). DOI: 10.1126 / sciadv.aba3200.