Sci Adv: Scientists have made a breakthrough in the study of the human diarrhea virus, enterodenovirus

Researcher Lars-Anders Carlson said: 'In this study, we gained an in-depth understanding of how viruses can be used through the stomach and gut system, continuous research or to provide answers as to whether the virus's properties are being used to develop new vaccine strategies.'
article, researchers looked at the virus EAdv, enteric adenovirus, one of the main causes of diarrhoea in infants, which causes more than 50,000 deaths a year among children under the age of 5, mainly in developing countries.
Most adenoviruses are respiratory viruses, i.e. they cause respiratory diseases, while little-known variants of enteroviruses cause gastrointestinal diseases, so enteroviruses need to be equipped to pass through the acidic environment of the stomach and not break down before infecting the intestinal tissue.
Using advanced cryogenic electronscope technology, researchers were able to successfully obtain detailed images of enterovirus, which would allow them to map a three-dimensional map and show the shape of the virus at the atomic level, where the virus is one of the most complex biological structures studied, and where the virus spreads between populations, the shell that protects the virus genome is made up of 2,000 protein molecules and 6 million atoms.
Researchers found that in a lower pH environment, enterodenoviruses try to maintain their structure, while researchers can also observe other differences between enterodenoviruses and respiratory adenoviruses, namely, how proteins on the virus shell are altered and new clues to clarify the mechanisms by which viruses wrap their genomes.
researcher Lars-Anders Carlson said: 'We hope to be able to turn the ability of this annoying virus into a special tool that can fight viruses, and even be used to fight COVID-19, which is a step in the right direction, but there is still a long way to go; The new vaccines being tested by VID-19 are genetically modified adenovirus, and now new adenovirus-based vaccines can be injected into the human body to work, and if the vaccine is based on the Western enterovirus, the vaccine developed will be edible, and it is expected to promote mass vaccination.
original source: K. Rafie, A. Lenman, J. Fuchs, et al. The structure of enteric human adenovirus 41—A leading cause of diarrhea in children, Science Advances (2021). DOI: 10.1126/sciadv.abe0974