Sci Adv: Scientists hope to develop novel therapy for small cell lung cancer

March 6, 2022 / Bio Valley BIOON / -- EP300 is a transcriptional cofactor that is very important in cell proliferation and differentiation, and is frequently mutated in various cancer types, including small cell lung cancer

In the article, the researchers sought to understand the key role that mutations in the EP300 gene play in the development of small cell lung cancer tumors.

"The most striking aspect of this study is that we explain the unique susceptibility of EP300 at the molecular level, down to an amino acid," said researcher Park.

In this study, the researchers proposed a potential new method.

Image source: https:// targeting KIX may be expected as a new method to treat small cell lung cancer in patients, and KIX may be a special weakness of small cell lung cancer; in order to reveal this weakness in depth, the researchers have previously considered targeting Scientists working on KIX domains work together

Taken together, our findings demonstrate that we uncover a domain-specific role of EP300 in small cell lung cancer and the unique susceptibility of the EP300 KIX domain in the treatment of novel therapeutic interventions

Original source:

KEE-BEOM KIM, ASHISH KABRA, DONG-WOOK KIM, et al.