Sci Adv: Targeted LANDO signaling paths can be used to treat Alzheimer's disease.

August 17, 2020 /--- a recent study from Scientists at Jude Children's Hospital have deepened their understanding of potential treatments for Alzheimer's disease.
they found that LC3-related endothrosis (LANDO) and its role in nerve inflammation.
the results are published today in the journal Science Advance.
previously discovered the LANDO pathway in small glial cells, the main immune cells of the brain and central nervous system.
scientists found that the process of Alzheimer's disease accelerated in mouse models after removing the genes needed for the pathway.
researchers have also shown that LANDO can prevent nerve inflammation.
(Photo: www.pixabay.com) continues to study LANDO, researchers have discovered new features of the ATG16L protein.
protein is essential for autophagy, a normal process by which cells recover their ingredients during stress or energy deficiency.
ATG16L is important for autophagy, it can also play a role in LANDO.
researchers found that if the WD domain of ATG16L is removed, the LANDO process is suppressed while the autophagy continues.
we understand this pathway in the context of brain tumor research, but it's important for neuroinflamm and neurodegenerative diseases," said Dr. Douglas Green, director of the Department of Immunology.
"We have shown that the lack of LANDO in mouse models, coupled with aging, can lead to Alzheimer's disease, and there is evidence that this may be the case in humans." in the
study, researchers used a new mouse model that had specific flaws in the WD domain of ATG16L, causing the LANDO pathway to be blocked even though the autophagy process was working properly.
mice by the age of 2, they showed symptoms and pathological characteristics similar to Alzheimer's disease in humans.
also analyzed tissue samples from Alzheimer's disease in humans and studied the expression of proteins that regulate LANDO, including ATG16L.
in Alzheimer's patients, the expression of these proteins decreased by more than 50 percent.
findings suggest a correlation between LANDO deficiency and aging in mouse models and humans that lead to Alzheimer's disease.
in treatment experiments, the researchers used a compound that inhibits inflammation of small bodies, and the results showed that drug therapy reduced neuroinflamm and improved cognition and memory.
(bioon.com) Source: Targeting the LANDO pathway a holds potential clue to Treating Alzheimer's Disease Source: B.L. Heckmann el al., "Noncanonical function of an autophagy protein prevents spontaneous Alzheimer's disease," Science Advances (2020). advances.sciencemag.org/lookup ... 1126 / sciadv.abb9036.