echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > Sci Adv: This cheap oral drug has doubled the effect of radiotherapy for cancer brain metastases!

    Sci Adv: This cheap oral drug has doubled the effect of radiotherapy for cancer brain metastases!

    • Last Update: 2021-12-04
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Advanced tumors often have brain metastases (BM).


    The blood-brain barrier refers to the barrier between blood plasma and brain cells formed by brain capillary walls and glial cells, and the barrier between plasma and cerebrospinal fluid formed by the choroid plexus, allowing only specific types of molecules to enter from the bloodstream Brain neurons and other surrounding cells


    Arginine, also known as L-arginine, is inexpensive and safe, and it passes through the blood-brain barrier relatively easily


    Recently, a research team from Cornell University in the United States and University College London has published a research paper titled: The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases in Science Advances .


    Science Advances The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases

    The study is a proof-of-concept randomized clinical trial that reports the results of oral arginine given before standard radiotherapy for 31 patients with brain metastases


    The research team first evaluated the expression of nitric oxide synthase (NOS) subtypes associated with tumors


    Then, the research team observed that the patient's tumor blood volume decreased significantly after taking L-arginine for 1 hour


    With these findings in mind, the research team conducted a proof-of-concept randomized clinical trial to determine whether L-arginine would increase the efficacy of radiotherapy for cancer patients with unresectable brain metastases


    In a mouse model of triple-negative breast cancer (TNBC), the research team observed that L-arginine inhibited tumor metabolism, and this inhibition occurred in a NOS2-dependent manner


    In summary, the study found that the administration of L-arginine directly affects the metabolism of cancer cells and affects the ability of cancer cells to survive sublethal DNA damage


    Original source:

    Original source:

    ROSSELLA MARULLO, et al.


    The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases

    in this message
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.