Sci Immunol: Scientists are expected to successfully manipulate bone marrow stem cells to convert them into congenital lymphocytes and natural killer cells

12, 2020 /PRY/ -- Scientists from institutions such as Colorado Children's Hospital successfully manipulated bone marrow stem cells to transform them into congenital lymphocytes and natural killer cells in a recent study published in the international journal Science Immunology entitled "Human innate lymphoid cells express express CD48 that modulates ILC differentiation via 2B4 signaling."
Photo Source: Bobjgalindo/Wikipedia The scientific community now recognizes that bone marrow stem cells can produce all types of blood cells, but researchers don't know the specific molecular mechanisms that drive this process, and in this study, researchers have revealed how natural killer cells that fight cancer develop, as well as how another type of blood cell called congenital lymphocytes is produced, with congenital lymphocytes primarily involved in multiple aspects of human body health and disease.
By understanding these factors, researchers may be able to manipulate stem cells and tailor new therapies for children and adult patients undergoing cancer therapy in the coming years, based on the results of this paper, the researchers applied for intellectual property protection around the methods used in the study.
researcher Professor Mike Verneris said: 'We are encouraged by this study and believe that more in-depth research at a later stage will better help develop new therapies to treat cancer patients in children and adults.'
'We were able to get the results of this paper in part by relying on the support of philanthropists to advance the research, and in addition to federal research funding, the investments made by generous donors have played a key role in our breakthrough research progress,' said Veneris, a researcher at the end of the study.
() Original source: Dejene M. Tufa, Ashley M. Yingst, George Devon Trahan, et al. Human innate lymphoid cell precursors express CD48 that modulates ILC differentiation through 2B4 signaling, Science Immunology (2020). DOI:10.1126/sciimmunol.aay4218。