Sci Immunol: Scientists have discovered new treatments that can effectively prevent and treat viral infections such as rotiss viruses.

11, 2020 // -- In a recent study published in the international journal Science Immunology, scientists from Georgia State University and other institutions found that combining two substances secreted by the body's immune system could treat and prevent rotovirus infections, as well as potentially treating viral infections in other targeted endocrine cells.
-wheeled virus can cause severe and life-threatening diarrhea in young children, as well as gastrointestinal discomfort in adults and thousands of child deaths each year, especially in developing countries where the rotovirus vaccine has only moderate effect, and is an RNA virus that mainly infects intestinal endocular cells.
In this study, the researchers identified specific substances in the cytokine class, namely lebines-18 (IL-18) and leuriatin-22 (IL-22), which produce IL-18 and IL-22 when the body detects the presence of special proteins in the whiplash-like appendages of bacteria.
photo source: Zhang et al., Sci.Immunol.5, eabd2876 (2020), the researchers reveal how these cytokines inhibited rotovirus infections, which promote each other when treating mice with IL-18 and IL-22 expression, but when used independently, it hinders the replication of the rota virus, which has different mechanisms for activating the subjects of the intestinal endocyst cells, which quickly and completely remove the infection of the rota virus, even in hosts where the immune system is severely impaired;
researcher Andrew Gewirtz said the study proposed a new way to effectively eliminate viral infections, especially those that infect intestinal endocrine cells, and the results showed that a mixture of IL-18 and IL-22 could be used to effectively treat viral infections in short-lived endocrine cells with high target turnover.
will continue to delve into developing new targeted therapies that are more effective in treating diarrhoeal virus infections such as rotissa.
() Original source: Zhan Zhang, Jun Zou, Zhenda Shi, et al. IL-22-induced cell extrusion and IL-18-induced cell death prevent and cure rotavirus, Science Immunology 02 Oct 2020: Vol. 5, Issue 52, eabd2876 DOI:10.1126/sciimmunol.abd2876.