Sci Rep: Biomarkers can be used to detect brain damage.

August 5, 2020 /--- -- A team of scientists led by the University of Arizona and the City of Hope Institute for Translational Genomics (TGen) has identified a new family of biomarkers through proteomics and metabolomic analysis that could help treat tens of millions of patients with brain damage and potentially prevent severe long-term disability.
results were published recently in the journal Scientific Reports.
estimates that 69 million people worldwide suffer brain trauma (TBI) each year.
, including at least 3 million in the United States, resulted in nearly 288,000 hospitalizations, 56,800 deaths and 90,000 permanent disabilities.
the practical application of the study (Photo source: www.pixabay.com) is the effectiveness of a brain injury treatment called RIC (remote ischemic conditioning).
Pirarotte's team used mouse models and advanced mass spectrometrical analysis tools to analyze proteins and metabolites to identify biomarkers that showed RIC effectiveness, as well as other biomarkers that could be used to measure the presence of damage.
study says that returning to normal or intense activity too early can worsen (TBI) conditions and trigger chronic health-related diseases, further exacerbating the onset of neurodegenerative diseases.
Khyati Pathak, a member of Dr. Prirotte's team and one of the study's authors, said, "The biomarkers we identified allowed us to measure the extent of damage and monitor RIC-assisted brain injury recovery."
" newly identified biomarkers can provide more accurate diagnosis of TBI molecular levels.
(bioon.com) Source: Scientists identifying robust of the biomarkers to help guide treatment for brain injuries Original source: Saber, M., et al. (2020) Proteomic analysiss identifies plasma correlates of remote ischemic conditioning in the context of the analysis of the brain injury. Scientific Reports. doi.org/10.1038/s41598-020-69865-4.