Sci Rep: New method to effectively avoid vaccine high temperature degradation

, June 10, 2020 /PRNewswire/ -- BioValley BIOON/--- is well known that vaccines are difficult to deliver to remote or dangerous locations because they need to be refrigerated and stored or they will deteriorateMost vaccines are safe in the temperature range of 2 to 8 degrees C, but at other temperatures, the protein denatures, leading to vaccine inactivationin a recent study, scientists found ways to prevent vaccines from degrading at high temperaturesBy encased in a silicone shell, the structure remains intact even when heated to 100 degrees C or kept at room temperature for up to three years(Photo:Researchers at the University of Newcastle have developed a technique using a silicon dioxide coating as a vaccine protective shellIn the latest study, published in the journal Scientific Reports, researchers used a regular mailing method of stoic-wrapped tetanus vaccine and routine vaccine samples (300 miles from cruise ship to cruise ship, which takes a day or two to deliver)A certain dose of the silicate-containing vaccine was then injected into the miceThe results showed that a vaccine with a protective shell could trigger an immune response in the body, indicating that the vaccine was activeIn contrast, no immune response was detected in mice vaccinated against the general vaccine, indicating that the drug was damaged during transportsilicon dioxide is an inorganic, non-toxic materialDrSartbaeva estimates that the silicate vaccine could be used in humans within five to 15 yearsShe hopes the technology will eventually be used to store and transport all childhood vaccines and other protein-based products, such as antibodies and enzymes(Bio Valley Bioon.com)Source:Scientistfind way to prevent-warm-up-vaccines from the of leper original origin: Doekhie, A., et al (2020) Enconcated tetanus anti-retaingens immunogencity: in vivo study and time-time--
time- Scientific Reports doi.org/10.1038/s41598-020-65876-3.