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March 25, 2021 //---It is well known that the learning and memory center of mammals is a structure called the hippocampus.
This structure has a remarkable ability to continuously produce new neurons throughout life.
Neonatal neurons are produced by neural stem cells (NSC), and they are essential for the formation of neural circuits required for learning, memory and emotional control.
During the aging process, the number of neural stem cells decreases, leading to reduced neurogenesis and age-related cognitive decline, anxiety and depression.
Therefore, if neurogenesis is to be used to halt or reverse age-related hippocampal pathologies, it is important to identify the molecular mechanisms responsible for NSC to maintain dryness.
This structure has a remarkable ability to continuously produce new neurons throughout life.
Neonatal neurons are produced by neural stem cells (NSC), and they are essential for the formation of neural circuits required for learning, memory and emotional control.
During the aging process, the number of neural stem cells decreases, leading to reduced neurogenesis and age-related cognitive decline, anxiety and depression.
Therefore, if neurogenesis is to be used to halt or reverse age-related hippocampal pathologies, it is important to identify the molecular mechanisms responsible for NSC to maintain dryness.
Although there are more and more tools available for studying NSC and neurogenesis in mouse models, one of the main obstacles to exploring this basic biological process in the human brain is the lack of specific NSCs suitable for advanced imaging and in vivo analysis Sign.
A team of researchers led by Dr.
Mirjana Maletić-Savatić, associate professor of Baylor College of Medicine and researcher of the Jan and Dan Duncan Institute of Neuroscience at Texas Children’s Hospital and Dr.
Louis Manganas, associate professor of Stony Brook University, decided to take a very unusual The way to solve this problem.
They believe that if they can find proteins on the surface of neural stem cells, they can eventually become drugs that "see" neural stem cells in the human brain.
A team of researchers led by Dr.
Mirjana Maletić-Savatić, associate professor of Baylor College of Medicine and researcher of the Jan and Dan Duncan Institute of Neuroscience at Texas Children’s Hospital and Dr.
Louis Manganas, associate professor of Stony Brook University, decided to take a very unusual The way to solve this problem.
They believe that if they can find proteins on the surface of neural stem cells, they can eventually become drugs that "see" neural stem cells in the human brain.
(Image source: www.
pixabay.
com)
pixabay.
com)
"The ultimate goal of our research is to maintain the level of neurogenesis in a young state for a long time to prevent people's cognitive decline as they age.
For this, we first need to better understand the basic processes.
However, we There are no tools to study this process in vivo.
So far, all the knowledge we have gathered comes from the analysis of the brains of dead donors,” said Maletić-Savatić.
"So, we collaborated with colleagues from New York and Spain to conduct this research.
By looking for surface markers, and then developing tools such as positron emission tomography (PET), we used advanced real-time in vivo brain imaging technology Visualize.
"
For this, we first need to better understand the basic processes.
However, we There are no tools to study this process in vivo.
So far, all the knowledge we have gathered comes from the analysis of the brains of dead donors,” said Maletić-Savatić.
"So, we collaborated with colleagues from New York and Spain to conduct this research.
By looking for surface markers, and then developing tools such as positron emission tomography (PET), we used advanced real-time in vivo brain imaging technology Visualize.
"
First, the research team set out to prepare specific antibody molecules against unknown target proteins.
They produced antibodies by injecting mice with whole cells or membrane preparations, and produced 1,648 clones, 39 of which were able to react with NSC.
After careful inspection, the author discovered the strongest target protein in NSC.
Mass spectrometry analysis identified the target protein as brain-enriched signaling protein 1 (BASP-1), which has previously been found to be highly expressed in mouse NSC.
At the same time, the specific antibody that recognizes BASP-1 does not interact with nerve cells or any other cells except NSC, which indicates that it can be used to label related cells in the brain of living mammals.
They produced antibodies by injecting mice with whole cells or membrane preparations, and produced 1,648 clones, 39 of which were able to react with NSC.
After careful inspection, the author discovered the strongest target protein in NSC.
Mass spectrometry analysis identified the target protein as brain-enriched signaling protein 1 (BASP-1), which has previously been found to be highly expressed in mouse NSC.
At the same time, the specific antibody that recognizes BASP-1 does not interact with nerve cells or any other cells except NSC, which indicates that it can be used to label related cells in the brain of living mammals.
With this newly discovered biomarker, scientists can better understand the relevance and complex mechanisms of neurogenesis, which may lead to new therapies in the future to treat and manage neurological diseases related to decreased neurogenesis And neuropsychiatric diseases.
The research was published in the journal "Scientific Reports".
(Bioon.
com)
The research was published in the journal "Scientific Reports".
(Bioon.
com)
Information source: com/news/2021-03-marker-adult-human-neural-stem.
html">A novel marker of adult human neural stem cells discovered
html">A novel marker of adult human neural stem cells discovered
Original source: Louis N.
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
(Image source: www.
pixabay.
com)
pixabay.
com)
"The ultimate goal of our research is to maintain the level of neurogenesis in a young state for a long time to prevent people's cognitive decline as they age.
For this, we first need to better understand the basic processes.
However, we There are no tools to study this process in vivo.
So far, all the knowledge we have gathered comes from the analysis of the brains of dead donors,” said Maletić-Savatić.
"So, we collaborated with colleagues from New York and Spain to conduct this research.
By looking for surface markers, and then developing tools such as positron emission tomography (PET), we used advanced real-time in vivo brain imaging technology Visualize.
"
For this, we first need to better understand the basic processes.
However, we There are no tools to study this process in vivo.
So far, all the knowledge we have gathered comes from the analysis of the brains of dead donors,” said Maletić-Savatić.
"So, we collaborated with colleagues from New York and Spain to conduct this research.
By looking for surface markers, and then developing tools such as positron emission tomography (PET), we used advanced real-time in vivo brain imaging technology Visualize.
"
First, the research team set out to prepare specific antibody molecules against unknown target proteins.
They produced antibodies by injecting mice with whole cells or membrane preparations, and produced 1,648 clones, 39 of which were able to react with NSC.
After careful inspection, the author discovered the strongest target protein in NSC.
Mass spectrometry analysis identified the target protein as brain-enriched signaling protein 1 (BASP-1), which has previously been found to be highly expressed in mouse NSC.
At the same time, the specific antibody that recognizes BASP-1 does not interact with nerve cells or any other cells except NSC, which indicates that it can be used to label related cells in the brain of living mammals.
They produced antibodies by injecting mice with whole cells or membrane preparations, and produced 1,648 clones, 39 of which were able to react with NSC.
After careful inspection, the author discovered the strongest target protein in NSC.
Mass spectrometry analysis identified the target protein as brain-enriched signaling protein 1 (BASP-1), which has previously been found to be highly expressed in mouse NSC.
At the same time, the specific antibody that recognizes BASP-1 does not interact with nerve cells or any other cells except NSC, which indicates that it can be used to label related cells in the brain of living mammals.
With this newly discovered biomarker, scientists can better understand the relevance and complex mechanisms of neurogenesis, which may lead to new therapies in the future to treat and manage neurological diseases related to decreased neurogenesis And neuropsychiatric diseases.
The research was published in the journal "Scientific Reports".
(Bioon.
com)
The research was published in the journal "Scientific Reports".
(Bioon.
com)
Information source: com/news/2021-03-marker-adult-human-neural-stem.
html">A novel marker of adult human neural stem cells discovered
html">A novel marker of adult human neural stem cells discovered
Original source: Louis N.
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
First, the research team set out to prepare specific antibody molecules against unknown target proteins.
They produced antibodies by injecting mice with whole cells or membrane preparations, and produced 1,648 clones, 39 of which were able to react with NSC.
After careful inspection, the author discovered the strongest target protein in NSC.
Mass spectrometry analysis identified the target protein as brain-enriched signaling protein 1 (BASP-1), which has previously been found to be highly expressed in mouse NSC.
At the same time, the specific antibody that recognizes BASP-1 does not interact with nerve cells or any other cells except NSC, which indicates that it can be used to label related cells in the brain of living mammals.
They produced antibodies by injecting mice with whole cells or membrane preparations, and produced 1,648 clones, 39 of which were able to react with NSC.
After careful inspection, the author discovered the strongest target protein in NSC.
Mass spectrometry analysis identified the target protein as brain-enriched signaling protein 1 (BASP-1), which has previously been found to be highly expressed in mouse NSC.
At the same time, the specific antibody that recognizes BASP-1 does not interact with nerve cells or any other cells except NSC, which indicates that it can be used to label related cells in the brain of living mammals.
With this newly discovered biomarker, scientists can better understand the relevance and complex mechanisms of neurogenesis, which may lead to new therapies in the future to treat and manage neurological diseases related to decreased neurogenesis And neuropsychiatric diseases.
The research was published in the journal "Scientific Reports".
(Bioon.
com)
The research was published in the journal "Scientific Reports".
(Bioon.
com)
Information source: com/news/2021-03-marker-adult-human-neural-stem.
html">A novel marker of adult human neural stem cells discovered
html">A novel marker of adult human neural stem cells discovered
Original source: Louis N.
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
With this newly discovered biomarker, scientists can better understand the relevance and complex mechanisms of neurogenesis, which may lead to new therapies in the future to treat and manage neurological diseases related to decreased neurogenesis And neuropsychiatric diseases.
The research was published in the journal "Scientific Reports".
(Bioon.
com)
The research was published in the journal "Scientific Reports".
(Bioon.
com)
Information source: com/news/2021-03-marker-adult-human-neural-stem.
html">A novel marker of adult human neural stem cells discovered
html">A novel marker of adult human neural stem cells discovered
Original source: Louis N.
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Information source: com/news/2021-03-marker-adult-human-neural-stem.
html">A novel marker of adult human neural stem cells discovered
Information source: com/news/2021-03-marker-adult-human-neural-stem. html">A novel marker of adult human neural stem cells discovered
Original source: Louis N.
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
html">A novel marker of adult human neural stem cells discovered
Original source: Louis N.
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Original source: Louis N.
Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
Original source: BASP1 labels neural stem cells in the neurogenic niches of mammalian brain Scientific Reports Manganas, Irene Durá, Sivan Osenberg et al, BASP1 labels neural stem cells in the neurogenic niches of mammalian brain , Scientific Reports (2021).
DOI: 10.
1038/s41598-021-85129-1
