Sci Rep: Study reveals the biological mechanisms of wound healing.

September 17, 2020 // --- our bodies have the ability to heal wounds on their own, such as cuts or bruises.
, however, patients with diabetes, vascular and skin diseases sometimes have difficulty recovering.
can lead to chronic wounds that can seriously affect the quality of life.
chronic wound management is the main cost of the health care system, costing about $1 billion to $20 billion a year in the United States alone.
, however, we know very little about why some wounds become chronic wounds, making it difficult to develop effective treatments to promote healing.
recent study described a novel method of sampling cells found in wounds using discarded wound dressings.
This non-invasive approach opens a window into the cellular composition of wounds and provides an opportunity to identify wound characteristics that may heal compared to chronic wounds and to provide information for the development of targeted treatments.
(Photo: www.pixabay.com) was published September 15 in the journal Scientific Reports.
, associate professor in the Department of Dermatology and Dermatology and one of the study's lead authors, said: "Studying wound healing in humans is challenging.
our current understanding of the event comes from animal studies, and animal skin and how it heals is very different from human skin.
South and his lab studied a group of hereditary skin diseases called large herpes skin looseness (EB), where wound healing is severely damaged.
patients often suffer from blisters and lesions from birth, healing slowly, and some even chronically.
in some patients, the risk of developing chronic wounds into aggressive skin cancer is high.
, it is difficult to predict which wounds will heal in a given patient and which will not.
ability to sample wounds is key to understanding the healing mechanism.
South said: "Biopsies to sample cells in the wound will help us understand the differences between these wounds, but biopsies in these patients are painful and may further slow the healing of the wound."
, on the other hand, collect these bandages that will be thrown away, are harmless to the patient, and can be used in a variety of situations in which the wound does not heal properly.
" researchers collected and analyzed 133 discarded wound dressings from 51 EB patients, including acute and chronic wounds, defined as persistent for 21 days or less, and chronically defined as persistent for more than 3 months.
South said: "Previous studies have used wound dressings or bandages to collect fluids and look at proteins there.
but no one has really looked at the cells that exist.
techniques often used in applied laboratories, we are able to isolate live cells or living cells from the dressing.
" researchers recovered a large number of cells from the dressing, usually more than 100 million.
the wound, the longer the dressing on the wound, the more cells are recycled.
the cells, the researchers personally typed them to see what types of cells were present on the wound.
they tested a variety of immune cells, including lymphocytes, granulocytes or neutral granulocytes, as well as monocytes or macrophages.
when comparing dressings for acute and chronic wounds, they found a significant increase in the number of nexual granulocytes at chronic wound sites.
are the first line of defense for our immune system, and when wounds begin to form, they are the first neutral granulocytes to arrive at the site.
South said:
The results from animal studies and protein analysis of human wound dressings suggest that the presence of neutrogenic granulocytes for too long can delay the healing process and lead to chronic diseases."
our findings suggest that chronic wounds are characterized by higher levels of nexual granulocytes, thus supporting this theory more clearly.
"these findings provide more insight into wound healing and may help develop therapies that promote this process."
such as those that neutralized excess neophilic white blood cells or raised macrophages, these immune cells begin the next stage of recovery after neophilic white blood cells.
(bioon.com) Source: A new approach to understanding the biology of the wound healing Original source: Ignacia Fuentes et al, Cells from from discarded dressings chronice from acute wounds with patients with Dedermolysis Bullosa, Scientific Reports (2020). DOI: 10.1038/s41598-020-71794-1.