Sci Rep: Study reveals the underlying mechanisms of joint damage.

March 20, 2020 // --- analepciss ligament (ACL) can lead to severe osteoarthritis.
now, a new interdisciplinary study suggests that the accumulation of proteins used to lubricate joints may actually be a precursor to joint disease.
paper, published recently in the journal Cell Reports, is the first to examine the role of a protein called lubricin in ACL-type damage in dogs.
may have a greater impact on similar harm to humans and on the potential for treatment and treatment.
(Photo: www.pixabay.com) Dr Heidi Reesink said: "Lubricin is essential for normal joint function and cartilage lubrication.
we know that if animals don't make this protein, they develop devastating joint disease that affects all major weight-carrying joints.
" lubricin is common to mammals, including humans, despite conflicting data on its role in joint damage.
Reesink's study found an increase in lubricin in the joints in canines with torn knee ligaments, contrary to traditional medical assumptions.
reesink said: "The previous central idea in this area has been lubricin to help reduce joint disease.
three dogs with joint injuries, lubricin had significantly more time between initial injuries but no signs of arthritis from X-rays.
suggests that the increased grease may actually be a biomarker for predicting future osteoarthritis," said Reesink, a research analyst at the U.S. Department of Health.
also found that lubricin increased significantly after a few months and years of injury, suggesting that lubricin may be an indicator of continued joint instability.
," Reesink said, adding lubricin could therefore act as a signal for clinicians to intervene or try different treatments.
(bioon.com) Source: Study upends understanding about joint injuries Source: Yuyan Wang et al. Synovial fluid lubricin increases in spontaneous canine cruciate ligament rupture, Scientific Reports (2020). DOI: 10.1038/s41598-020-73270-2.