Sci Rep: The role of lower high-sensitivity troponin I cutoff in early cardiac injury identification in non-severe COVID-19 patients

Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARSCov-2), has impacted global health on an unprecedented scale, and the number of global cases continues to rise
.

Although COVID-19 is primarily considered a respiratory infection, it has important systemic effects, such as cardiac damage, which have been shown to be a significant factor in mortality in COVID-19 patients

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARSCov-2), has impacted global health on an unprecedented scale, and the number of cases worldwide continues to rise

These include acute heart injury, myocarditis, arrhythmias, heart failure, and cardiogenic shock

Methods: In this study, 113 non-severe COVID-19 patients were grouped according to symptom onset duration of hospitalization: group 1 (≤1 week, n ​​= 27), group 2 (>1 to 2 weeks, n = 28), 3 group (>2 to 3 weeks, n = 27), group 4 (>3 weeks, n = 31)
.

Clinical, cardiovascular, and radiological data at the time of hospitalization were compared among the four groups

Results: The levels of high-sensitivity troponin I (hs-cTnI) [10.
25 (IQR 6.
75-15.
63) ng/L] in group 2 were significantly higher than those in group 1 [1.
90 (IQR 1.
90 - 8.
80) ng/L] and group 4 [ 1.
90 (IQR 1.
90 - 5.
80) ng/L] (both Pbonferroni < 0.
05)
.

The proportion of patients with hs-cTnI level ≥5 ng/L in the two groups (85.

Table 1
.

Comparison of demographic .

Table 1

Table 2
.

Comparison of cardiac biomarkers, CRP, lymphocyte counts, and radiological outcomes among the four groups

Table 2

Figure 1
.

Scatter plots of cardiac biomarkers and SPO2, lymphocyte count and CRP

Figure 1
.
Scatter plots of cardiac biomarkers and SPO2, lymphocyte count and CRP
.
Cardiac biomarker levels were significantly correlated with SPO2, lymphocyte count and CRP
.
SPO2, pulse oximetry; CRP, c-reactive protein; hs-cTnI, high-sensitivity troponin I; BNP, b-type natriuretic peptide; CKMB, creatine kinase myocardial band; LDH, lactate dehydrogenase
.

Figure 2
.
Simulated changes in cardiac biomarkers in four groups of non-severe COVID-19 patients
.
The levels of hs-cTnI, myoglobin, BNP, and LDH were the highest in the second week after the onset of COVID-19 patients
.
hs-cTnI, high-sensitivity troponin I; BNP, b-type natriuretic peptide; LDH, lactate dehydrogenase; ULR: upper reference interval; LLR, lower reference interval
.

Figure 2
.
Simulated changes in cardiac biomarkers in four groups of non-severe COVID-19 patients
.
The levels of hs-cTnI, myoglobin, BNP, and LDH were the highest in the second week after the onset of COVID-19 patients
.
hs-cTnI, high-sensitivity troponin I; BNP, b-type natriuretic peptide; LDH, lactate dehydrogenase; ULR: upper reference interval; LLR, lower reference interval
.

Figure 3
.
Simulated changes in SpO2, lymphocyte count, CRP, and radiological outcomes in four groups of non-severe COVID-19 patients
.
Patients with COVID-19 had the highest CRP levels and lowest SpO2 and lymphocyte counts in the second week after symptom onset
.
At the same time, patients had the highest incidence of bilateral pneumonia
.
SPO2, pulse oximetry; CRP, c-reactive protein; ULR: upper limit of reference interval; LLR, lower limit of reference interval
.

Figure 3
.
Simulated changes in SpO2, lymphocyte count, CRP, and radiological outcomes in four groups of non-severe COVID-19 patients
.
Patients with COVID-19 had the highest CRP levels and lowest SpO2 and lymphocyte counts in the second week after symptom onset
.
At the same time, patients had the highest incidence of bilateral pneumonia
.
SPO2, pulse oximetry; CRP, c-reactive protein; ULR: upper limit of reference interval; LLR, lower limit of reference interval
.

Conclusions: Non-severe COVID-19 patients were most likely to develop cardiac injury in the second week after symptom onset
.
hs - cTnI≥5 ng/L may be a manifestation of early cardiac injury in patients
.

Non-severe COVID-19 patients were most likely to develop heart damage in the second week after symptoms began
.
hs - cTnI≥5 ng/L may be a manifestation of early cardiac injury in patients
.

Original source: Lin Y, Yan K, Chen L, et al.
Role of a lower cutoff of high sensitivity troponin I in identification of early cardiac damage in non-severe patients with COVID-19.
Sci Rep 2022 Feb 11;12(1 ) 

Role of a lower cutoff of high sensitivity troponin I in identification of early cardiac damage in non-severe patients with COVID-19.
Leave a comment here