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    Home > Active Ingredient News > Antitumor Therapy > Sci Sign: "Greedy" cancer cells multiply and spread through the energy produced by glycolysis

    Sci Sign: "Greedy" cancer cells multiply and spread through the energy produced by glycolysis

    • Last Update: 2020-06-05
    • Source: Internet
    • Author: User
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    Introduction: Sugar is the main food of cancer cells, sugar enters the body will be hydrolyzed into glucose, all our body's cells (including cancer cells) need glucose to provide energyCancer cells are "overbearing" and have more than 10 times the ability to absorb glucose than normal cells, but it uses only about 5% of the calories of glucose to produce a large amount of lactic acid, which inhibits the activity of T-cells and accelerates the growth of cancer cellsBecause cancer cells are insatiable to glucose, locating areas where human cells consume large amounts of glucose can help identify cancerin order to promote the rapid proliferation of tumor cells, tumor cells rely on glycolysis, a primitive metabolic pathway that can easily be used by cancer cells to obtain the energy to grow and diffuseglycoenzyme, the oldest form of energy generation in living cells, has existed for billions of years and existed before oxygen accumulated on Earth, the first form of energy production for primitive life on Earththis process includes the breakdown of glucose to produce the energy needed for molecular metabolic activityBacteria use glycolysis, and more complex organisms, such as plants and animals, also use glycolysisHowever, the latter has developed more complex forms of energy production, although there are more complex forms of energy production, although the electron delivery chain produces more ATP energy molecules than glycozy, however, many types of tumor cells still prefer to use glycolysis to provide sufficient energy for growth and proliferationDr Jeremy Blaydes and Charles Braydes, of the Cancer Science Unit at the University of Southampton School of Medicine, UKDrCharles NBirts reports that the high frequency of high glycolysis in cancer cells is still an established characteristic of many human tumorsThis energy-producing process provides metabolites to cancer cells, precursors that can act as an anabolic pathwayBleds and Burts, writing with a team of researchers, found some surprising new phenomena in in vitro breast cancer models, known as glycozy stress responses, involving p53, a p53 gene that carries a DNA blueprint called tumor p53 protein, which plays a key role in cell activity such as cell division and deathLong-term studies have shown that mutations in the p53 gene can cause cancer cells to grow and spread"The Warburg effect of constituent aerobic sugar enzymes is a marker of cancer cells, commonly caused by mutations in cancer-causing and cancer-suppressing genes," Bleds and Burts wrote in the journal Science Signals Cancer researchers concluded, "The Waberg effect has a variety of effects on cancer cells, including the ability to produce adenosine triphosphate (ATP), which reduces atP production dependence on oxygen, thereby reducing the potentially destructive reactive oxygen species (ROS) produced by the mitochondrial electron transmission chain." In the 1920s, Otto Warburg confirmed that cultured cancer cells have high glucose intake and lactic acid secretion, even when oxygen is not needed These three properties, glucose intake, lactic acid secretion and anaerobic energy creation are all hallmarks of the Waberg effect Waberg was a German scientist in the early 20th century, the first scientist to study sea urchin eggs, but in 1923 he turned his attention to rat tumors This shift has had a lasting impact on the field of oncology biology, especially in understanding the energy generation and use of tumor cells Waberg notes that tumor cells promote their own growth by absorbing large amounts of glucose from the host's blood Currently, positron emission scanning can help identify cancers by locating areas where human cells consume large amounts of glucose, which are easily identified because they are insatiable to glucose in addition, cancer cells always choose ancient metabolic pathways, glycolysis, to produce energy Waberg realized that cancer cells had found a way to ensure their survival by using the oldest energy production on the planet, and that the Waberg effect was estimated to be in 80 percent of cancers now, a team at the University of Southampton is revealing the energy production of cancer cells by focusing on the p53 gene The researchers found that the protein was regulated by "aerobic glycolysis" in cancer cells, which was further mediated by the CtBP family's NADH-dependent transcription factors, which Waberg never expected "By providing glucose-6 phosphoric acid for the oxidation of glycolysis, glycolysis also promotes the production of a reduced form of saline amine adenine dinucleotide phosphate, which provides a reduced equivalent for the protection of reactive oxygen species," the team said "
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