Sci Trans Med: New research could help treat Parkinson's.

September 13, 2020 /--- In a recent study, scientists have identified the genetic causes behind some Parkinson's disease and identified potential drug treatments.
research team led by Professor Rejko Krüger of the Luxembourg System Biomedical Centre (LCSB) of the University of Luxembourg experimented with patient-based cell culture in the laboratory.
results were published in the journal Science Translational Medicine.
(Photo: www.pixabay.com) A protein called DJ-1 plays a vital role in maintaining nerve cell function.
if the body can't produce a lot of DJ-1, important nerve cells will die.
result is a seizure of neurodegenerative diseases such as Parkinson's disease.
the production of important proteins such as DJ-1 may be permanently disrupted or halted if important genetic maps or the production processes they encode are defective.
the first time, Professor Rejko Krüger identified errors in DJ-1 synthesis, known as "stitching" in the development of some form of Parkinson's disease.
in patients, the basic tools for assembling protein DJ-1 do not dock properly.
", in scientific terms, we call it an exon jump.
protein cannot be produced because of this defect.
" study provides a whole new target for the drug treatment of this protein synthesis failure.
first author, Dr Ibrahim Boussaad, said: "This insight fundamentally changes our view of the cause of the disease and raises new possibilities for treatment.
"s precise bioinficional algorithms developed on LCSB enabled the team to immediately and automatically search for possible drugs and eventually discover the active compounds benzodiacytes and RETAS.
combination of two active substances allows cells to reactivate the synthesis process of DJ-1. "
combination of medical practice to laboratory research to computer science can we understand the cause and identify the active substances that may be used for treatment at the same time," explains Professor Rejko Krüger, a professor at the University of London.
.com Source: Stem cell research source: Stem cell research delivers new points of attack against St Parkinson's disease Source: Ibrahim Boussaad et al. A patient-base model of RNA mis-splicing freshs treatment targets in Parkinson's disease, Science Translational Medicine (2020). DOI: 10.1126/scitranslmed.aau3960.