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Sci Transl Med: Adrenergic system as a target to inhibit neuroinflammation after cerebral hemorrhage

 Last Update: 2021-04-23
 Source: Internet
 Author: User

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In patients with cerebral hemorrhage, myeloid cells increase in blood circulation, and peripheral immune cells infiltrate the brain parenchyma.

Immune Stem Cells

Acute brain injury mobilizes white blood cells to migrate to the perivascular space and brain parenchyma.

Blood vessel

A lot of knowledge about neuroimmune interactions and their potential clinical relevance has been gained from the brain and periphery (lymph nodes and spleen).

The crosstalk between CNS and the immune system is a highly coordinated process controlled by adrenergic innervation.

ICH tilts bone marrow hematopoietic stem cells to the lineage of bone marrow cells.

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β3- Adrenaline can stimulate the hematopoiesis of Ly6 ^Clow monocytes and inhibit neuroinflammation after cerebral hemorrhage.

The brain has a self-protection mechanism that mobilizes a unique population of monocytes through β3-adrenergic innervation, which directly point to the injured brain.

sciencemag.

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