Science Advance: A high-fat, low-carb ketogenic diet can help quit drinking and reduce the "lust" of drinking

Wine is one of the main drinks in human life, and the "wine culture" has been passed down for thousands of years.

Long-term drinking will increase the consumption of acetic acid and ketone bodies in the brain, and the ketogenic diet (KD), which is characterized by high fat and low carbohydrate water, can increase the ketone bodies in plasma and brain by breaking down fat in the liver.

Therefore, researchers from the National Institute of Alcohol Abuse and Alcoholism in the United States and the University of Pennsylvania jointly explored the effect of the ketogenic diet on the control of alcohol intake, and published a titled "Ketogenic diet reduces alcohol withdrawal symptoms" on Science Advance.

The researchers first compared the ketogenic diet (KD: 80% fat, 15% protein and 5% carbohydrate) and the standard American diet (SA: 35% fat, 15% protein and 50% carbohydrate) in the clinical process for alcohol abuse disorders.

Under KD and SA diet, the use of benzodiazepines within a week

After further using functional magnetic resonance imaging (fMRI) to analyze the patients' cravings for alcohol under different diets, the researchers found that the KD group had significantly lower alcohol cravings than the SA group in the third week of the change in eating habits .

Analysis under fMRI technology

In preclinical trials, the researchers tested the blood glucose and ketone levels of rats under the ketogenic diet and low-fat diet, and found that the rats under the ketogenic diet had lower glucose levels and higher ketone levels, and The body weight of the ketogenic diet rats was significantly lower than that of the low-fat diet rats.

Blood glucose and ketone levels in rats under KD and low-fat diet

Alcohol intake of rats with different eating habits

Overall, this study reveals the beneficial effects of the ketogenic diet in abstaining from alcohol and reducing alcohol consumption, and also provides a diet-based treatment method for the treatment of AUD patients to reduce alcohol intake.

Original source:

Leandro F.