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    Home > Active Ingredient News > Digestive System Information > Science Advance: A high-fat, low-carb ketogenic diet can help quit drinking and reduce the "lust" of drinking

    Science Advance: A high-fat, low-carb ketogenic diet can help quit drinking and reduce the "lust" of drinking

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    Wine is one of the main drinks in human life, and the "wine culture" has been passed down for thousands of years.
    However, as the saying goes, "drinking for pleasure, drinking too much hurts the body", in recent years, the global total alcohol consumption per capita over 15 years of age has continued to increase, and the improper use of alcohol has now become a major public health problem.
    Currently, there are about 2.
    3 billion people who drink alcohol globally, of which about 237 million men and 46 million women suffer from alcohol use disorder (AUD).
    AUD is a chronic recurrent brain disease that makes people have a strong desire for alcohol, and it is difficult to control alcohol intake.
    The death rate accounts for 5% of the global deaths.

    Long-term drinking will increase the consumption of acetic acid and ketone bodies in the brain, and the ketogenic diet (KD), which is characterized by high fat and low carbohydrate water, can increase the ketone bodies in plasma and brain by breaking down fat in the liver.

    Therefore, researchers from the National Institute of Alcohol Abuse and Alcoholism in the United States and the University of Pennsylvania jointly explored the effect of the ketogenic diet on the control of alcohol intake, and published a titled "Ketogenic diet reduces alcohol withdrawal symptoms" on Science Advance.
    "in humans and alcohol intake in rodents" report provides clinical and preclinical evidence that the ketogenic diet can reduce the need for drug use and physiological "cravings" in AUD patients, as well as reduce alcohol intake in alcohol-dependent rats.

    The researchers first compared the ketogenic diet (KD: 80% fat, 15% protein and 5% carbohydrate) and the standard American diet (SA: 35% fat, 15% protein and 50% carbohydrate) in the clinical process for alcohol abuse disorders.
    (AUD) The influence of benzodiazepines (sedative and anti-anxiety effects) in hospitalized patients.
    It was found that with the change of dietary habits, patients in the ketogenic diet group used benzodiazepines at a lower dose than the American diet Group, this shows that the ketogenic diet can reduce the demand for benzodiazepines.

    Under KD and SA diet, the use of benzodiazepines within a week

    Under KD and SA diet, use of benzodiazepines within one week, under KD and SA diet, use of benzodiazepines within one week

    After further using functional magnetic resonance imaging (fMRI) to analyze the patients' cravings for alcohol under different diets, the researchers found that the KD group had significantly lower alcohol cravings than the SA group in the third week of the change in eating habits .
    The dorsal anterior cingulate cortex (dACC) inhibits control, decision-making, and reward.
    Therefore, the dACC area is observed under fMRI and changes over time.
    Compared with the American diet group, the dACC area of ​​the ketogenic diet group is activated higher and the activation time Longer.

    Analysis under fMRI technology

    Analysis under fMRI technology Analysis under fMRI technology

    In preclinical trials, the researchers tested the blood glucose and ketone levels of rats under the ketogenic diet and low-fat diet, and found that the rats under the ketogenic diet had lower glucose levels and higher ketone levels, and The body weight of the ketogenic diet rats was significantly lower than that of the low-fat diet rats.

    Blood glucose and ketone levels in rats under KD and low-fat diet

    The blood glucose and ketone levels of rats under KD and low-fat diet.
    The blood glucose and ketone levels of rats under KD and low-fat diet.

    The researchers further exposed the rats that had been cultured on a ketogenic diet for 2 months and the rats that were freely edible to alcohol vapor for 7 weeks, thereby causing the rats to develop alcohol dependence.
    The amount of alcohol consumed by rats on their own initiative was significantly higher than that of rats under the KD diet.
    This shows that in a rat model of alcohol dependence, a ketogenic diet can reduce alcohol intake.

    Alcohol intake of rats with different eating habits

    Alcohol intake of rats with different eating habits history Alcohol intake of rats with different eating habits history

    Overall, this study reveals the beneficial effects of the ketogenic diet in abstaining from alcohol and reducing alcohol consumption, and also provides a diet-based treatment method for the treatment of AUD patients to reduce alcohol intake.

    Original source:

    Original source:

    Leandro F.
    Vendruscolo, et al.
    sciencemag.
    org/content/7/15/eabf6780" target="_blank" rel="noopener">Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents.
    Science Advances 09 Apr 2021: Vol.
    7, no.
    15, eabf6780.
    DOI: 10.
    1126/sciadv.
    abf6780.

    sciencemag.
    org/content/7/15/eabf6780" target="_blank" rel="noopener">Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents.


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