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    Home > Biochemistry News > Biotechnology News > Science Advances: Key factors promoting the reprogramming of human stem cells to a naïve state

    Science Advances: Key factors promoting the reprogramming of human stem cells to a naïve state

    • Last Update: 2022-04-24
    • Source: Internet
    • Author: User
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    Image: Immunofluorescence microscopy images showing different morphologies of reprogrammed pluripotent stem cells (orange) and unreprogrammed cells (purple)



    Researchers from the Babraham Institute's Epigenetics Research Program have been able to learn more about a genome-wide screen for reprogramming of naïve stem cells


    Human pluripotent stem cells (PSCs) are a useful tool for researchers to study how cells differentiate into every tissue in our body


    Group leader Peter Rugg-Gunn explained the importance of these cells: "Human PSCs in a naïve state replicate key molecular and cellular characteristics of cells in the preimplantation stage


    Pluripotent stem cells are either formed from embryos or removed from specialized cells using a Nobel Prize-winning method


    PhD student Adam Bendall, lead researcher on the study, said: "We know very little about the genetic and epigenetic factors required for naïve cell reprogramming, and this knowledge gap limits the design of reprogramming conditions


    The low efficiency of naïve reprogramming suggests that there are barriers preventing cells from reaching the naïve state


    The team focused specifically on an epigenetic complex, the PRC1.


    After identifying the factors that promote reprogramming, the researchers also looked at factors that hinder it, using an epigenetic protein called HDAC2 as an example in their study


    Not only does this study advance scientists' ability to produce human naïve PSCs, it also provides details of the molecular events that occur during cell state transitions, some of which are conserved in the developmental regulation of human embryos


    The Roger-Gun lab is piecing together an even bigger puzzle — the best understanding of how naïve stem cells are formed and controlled


    article title

    Genome-Wide Screening Identifies Polycomb Repressive Complex 1.



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