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Researchers from the Babraham Institute's Epigenetics Research Program have been able to learn more about a genome-wide screen for reprogramming of naïve stem cells
Human pluripotent stem cells (PSCs) are a useful tool for researchers to study how cells differentiate into every tissue in our body
Group leader Peter Rugg-Gunn explained the importance of these cells: "Human PSCs in a naïve state replicate key molecular and cellular characteristics of cells in the preimplantation stage
Pluripotent stem cells are either formed from embryos or removed from specialized cells using a Nobel Prize-winning method
PhD student Adam Bendall, lead researcher on the study, said: "We know very little about the genetic and epigenetic factors required for naïve cell reprogramming, and this knowledge gap limits the design of reprogramming conditions
The low efficiency of naïve reprogramming suggests that there are barriers preventing cells from reaching the naïve state
The team focused specifically on an epigenetic complex, the PRC1.
After identifying the factors that promote reprogramming, the researchers also looked at factors that hinder it, using an epigenetic protein called HDAC2 as an example in their study
Not only does this study advance scientists' ability to produce human naïve PSCs, it also provides details of the molecular events that occur during cell state transitions, some of which are conserved in the developmental regulation of human embryos
The Roger-Gun lab is piecing together an even bigger puzzle — the best understanding of how naïve stem cells are formed and controlled
article title
Genome-Wide Screening Identifies Polycomb Repressive Complex 1.