Science Advances: Odontoblasts TRPC5 channel is a signal of tooth cold pain, which can be used as a new target for the treatment of toothache

Tooth decay is a chronic disease in which the bacterial biofilm on the surface of the tooth combines with the fermentable carbohydrate matrix, leading to demineralization and ultimately to tooth decay.

Tooth decay is a chronic disease in which the bacterial biofilm on the surface of the tooth combines with the fermentable carbohydrate matrix, leading to demineralization and ultimately to tooth decay.

Pxiabay.

"This is a unique kind of pain," said Professor David Clapham, Associate Dean and Chief Scientific Officer of the Howard Hughes Medical Institute (HHMI) .

Professor David Clapham

Now, he and an international team of scientists have figured out how teeth perceive cold, and have determined the molecular and cellular factors involved.

In mice and humans, tooth cells called odontoblasts contain cold-sensitive proteins that detect temperature drops.

This study explains how an ancient home remedy relieves toothache.

It is possible to develop more specific drugs for this sensor to eliminate the sensitivity of teeth to cold.

No one knows how teeth perceive cold.

"We cannot rule out this theory," but there is no direct evidence to support it, says Clapham , a neurobiologist at HHMI .

Zimmermann and Clapham and their research team did not intend to study teeth.

When Zimmermann was a postdoctoral fellow in Clapham's laboratory about 15 years ago, the research team discovered that an ion channel called TRPC5 is very sensitive to cold.

After that, "We entered a dead end," Zimmermann said.

TRPC5 is necessary for inflammatory toothache

TRPC5 is necessary for inflammatory toothache TRPC5 is necessary for inflammatory toothache TRPC5 is necessary for inflammatory toothache

Jochen Lennerz, a pathologist at Massachusetts General Hospital who was a co-author of the study , found that TRPC5 is indeed present in the teeth after examining adult specimens, and even more so in decayed teeth.

Jochen Lennerz, a pathologist at Massachusetts General Hospital who was a co-author of the study , found that TRPC5 is indeed present in the teeth after examining adult specimens, and even more so in decayed teeth.

A new experiment conducted on mice convinced the researchers that TRPC5 does indeed function as a cold sensor.

The pain receptors of the teeth respond to cold much more than the pain receptors of the skin.

The response of tooth pain receptors to cold is much greater than that of skin pain receptors.
Tooth pain receptors respond to cold more than skin pain receptors.
Tooth pain receptors respond to cold more than skin.
Of pain receptors respond much more to cold

The research team tracked the location of the odontoblasts of TRPC5 between the pulp and dentin.
When a person with exposed dentin bites a popsicle, those TRPC5 cells will feel cold and send an "Oh!" signal to the brain.
Make you feel extraordinary pain!

The research team tracked the location of the odontoblasts of TRPC5 between the pulp and dentin.
When a person with exposed dentin bites a popsicle, those TRPC5 cells will feel cold and send an "Oh!" signal to the brain.
Make you feel extraordinary pain! The research team tracked the location of the odontoblasts of TRPC5 between the pulp and dentin.
When a person with exposed dentin bites a popsicle, those TRPC5 cells will feel cold and send an "Oh!" signal to the brain.
Make you feel extraordinary pain!

This keen sense has not been studied as extensively as in other scientific fields.
Toothache may not be a fashionable topic, "but it is important and affects many people.
"

This keen sense has not been studied as extensively as in other scientific fields.
Toothache may not be a fashionable topic, "but it is very important and affects many people.
" This keen sense has not been studied as extensively as in other scientific fields.
Toothache may not be a fashionable topic, "but it is very important and affects many people.
" This keen sense has not been studied as extensively as in other scientific fields.
Toothache may not be a fashionable topic, "but it is important and affects many people.
"

References: Laura Bernal, Pamela Sotelo-Hitschfeld, Christine König, Viktor Sinica, Amanda Wyatt, Zoltan Winter, Alexander Hein, Filip Touska, Susanne Reinhardt, Aaron Tragl, Ricardo Kusuda, Philipp Wartenberg, Allen Sclaroff, John Dien Pfeifer, Fab Ectors, Andreas Dahl, Marc Freichel, Viktorie Vlachova, Sebastian Brauchi, Carolina Roza, Ulrich Boehm, David E.
Clapham, Jochen K.
Lennerz, Katharina Zimmermann.
  Odontoblast TRPC5 channels signal cold pain in teeth .
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