Science Advances Wei Wensheng's research team and collaborators reveal for the first time the three-dimensional structure of chromatin stable chromatin and the mechanism of cell homeostasis by the "useless" sequence of the genome

The non-coding sequences in the human genome play a vital role in a variety of biological processes, such as non-coding RNA, promoters, enhancers, and transposons

On November 3, 2021, University of California San Diego (UCSD) Wang Wei's group and Peking University Wei Wensheng's group jointly published a noncoding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability on Science Advances.

This study is based on 5-kb resolution Hi-C data from 7 human normal cell lines and cancer cell lines (Rao et al .

Figure 1 Discovery of hub sites and high-throughput functional screening

The selected hub sites do not overlap with any protein-coding genes, non-coding RNAs and TADs, and 77.

Figure 2 Excision of the hub site results in simultaneous changes in the three-dimensional structure of chromatin and gene expression

Dr.

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